Volume 555 Issue 7696



Computer algorithms to detect disease show great promise, but they must be developed and applied with care.

doi: 10.1038/d41586-018-03067-x


The sleeping bear of Russian science could finally wake — and China can show it how.

doi: 10.1038/d41586-018-03066-y


They sound dull, but data-management plans are essential, and funders must explain why.

doi: 10.1038/d41586-018-03065-z



Blockchain could let people offer health records for research — without losing control over them.

doi: 10.1038/d41586-018-02641-7


With corporate participation, researchers seek to build a pilot fusion energy plant within 15 years.

doi: 10.1038/d41586-018-02966-3


Major expedition will investigate enigmatic sea-floor fault zone.

doi: 10.1038/d41586-018-02640-8


Researchers are concerned about potential restrictions to academic freedom.

doi: 10.1038/d41586-018-02842-0


With Vladimir Putin set to earn another presidential term, researchers wonder whether his government will reverse decades of decline.

doi: 10.1038/d41586-018-02872-8

News Features


Like oil in water, the contents of cells can segregate into droplets. It’s called phase separation, and biologists are seeing it everywhere.

doi: 10.1038/d41586-018-03070-2

News & Views


Seismic waves that propagate through a layer of Earth’s upper mantle are highly attenuated. Contrary to general thinking, this attenuation seems to be strongly affected by oxidation conditions, rather than by water content.

doi: 10.1038/d41586-018-02828-y


Neurons are born in the brain’s hippocampus throughout adulthood in mammals, contributing to the region’s functions in memory and mood. But a study now questions whether this phenomenon really extends to humans.

doi: 10.1038/d41586-018-02629-3


Two analyses of the genetic alterations that characterize paediatric cancers reveal key differences from adult cancers, and point to ways of optimizing therapeutic approaches to combating cancer in children.

doi: 10.1038/d41586-018-01648-4


The experimental discovery of materials known as higher-order topological insulators corroborates theoretical predictions and expands the toolbox for integrated optics and mechanical devices.

doi: 10.1038/d41586-018-02868-4


Melanins are enigmatic pigments that have many roles, and the melanin in pathogenic fungi can aid host infection. Identification of a mammalian protein that recognizes melanin now reveals an antifungal defence pathway.

doi: 10.1038/d41586-018-02370-x



Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

doi: 10.1038/nature25480


The high-resolution structure of the entire eukaryotic oligosaccharyltransferase complex is determined, revealing the role of membrane lipids in mediating inter-subunit interactions, and the mechanism by which the complex enables protein N-glycosylation.

doi: 10.1038/nature25755



Fourteen stars from stellar overdensities above and below the Galactic disk have the same elemental abundances as disk stars, suggesting that these stars originated in the disk, perhaps being removed during interaction with passing dwarf galaxies.

doi: 10.1038/nature25490


A confocal scanning technique solves the reconstruction problem of non-line-of-sight imaging to give fast and high-quality reconstructions of hidden objects.

doi: 10.1038/nature25489


A two-dimensional phononic quadrupole topological insulator is demonstrated experimentally using mechanical metamaterials, which has both the one-dimensional edge states and the zero-dimensional corner states predicted by theory.

doi: 10.1038/nature25156


A quantized quadrupole topological insulator composed of capacitively coupled microwave resonators has corner states that are protected by bulk topology and exhibit exceptional robustness against edge deformation.

doi: 10.1038/nature25777


High-resolution nuclear magnetic resonance spectroscopy at the scale of single cells is achieved by combining a magnetometer consisting of an ensemble of nitrogen–vacancy centres with a narrowband synchronized readout protocol.

doi: 10.1038/nature25781


Redox conditions and associated defect chemistry rather than water content, as previously thought, strongly influence the seismic properties of olivine, the main constituent mineral of Earth’s upper mantle.

doi: 10.1038/nature25764


A derivation of Hamilton’s rule that considers explicit environmental stochasticity can predict when organisms should pay a cost to influence the variance in the reproductive success of their relatives, formalizing the link between bet-hedging and altruism.

doi: 10.1038/nature25965


Millions of Chinese smallholder farmers were persuaded to adopt enhanced management practices, which led to a greater yield, reduced nitrogen fertilizer use and improved environmental performance throughout China.

doi: 10.1038/nature25785


In lowland tropical forests in Panama, widespread species-level phosphorus limitation of tree growth is not reflected in community-wide growth or biomass owing to the presence of a few species tolerant of low phosphorus availability.

doi: 10.1038/nature25789


Analysis of the genomes, exomes and transcriptomes of 1,699 childhood cancers identifies 142 driver genes.

doi: 10.1038/nature25795


Recruitment of young neurons to the hippocampus decreases rapidly during the first years of life, and neurogenesis does not continue, or is extremely rare, in the adult human brain.

doi: 10.1038/nature25975


The C-type lectin receptor MelLec recognizes DHN-melanin in conidial spores of Aspergillus fumigatus and other DHN-melanized fungi, revealing an important role for this receptor in antifungal immunity in both mice and humans.

doi: 10.1038/nature25974


The EWS–FLI1 fusion protein, expressed in Ewing sarcoma, increases global transcription, causes accumulation of R loops and replication stress, and impairs BRCA1-mediated repair.

doi: 10.1038/nature25748


Gonadal germline epigenetic reprogramming involves an interplay between DNA methylation, the polycomb complex and Tet1 in both DNA methylation dependent and independent roles, to ensure the activation of a specific subset of genes critical for progression of gametogenesis.

doi: 10.1038/nature25964


X-ray and cryo-electron microscopy structures of the acid-sensing ion channel ASIC1a reveal the molecular mechanisms of channel gating and desensitization.

doi: 10.1038/nature25782