Volume 553 Issue 7686



Tracking societal impacts encourages academics to pursue them. The launch of three new Nature journals should also help.

doi: 10.1038/d41586-017-08943-6



Neural networks are making biological images easier to process.

doi: 10.1038/d41586-018-00004-w


Silicon Valley philanthropy project revives some grants rejected by a mainstream US biomedical funder.

doi: 10.1038/d41586-017-08795-0


The National Institutes of Health will again fund research that makes viruses more dangerous.

doi: 10.1038/d41586-017-08837-7


Moon missions, ancient genomes and a publishing showdown are set to shape the new year.

doi: 10.1038/d41586-018-00009-5

News Features


Research into this debilitating disease has a rocky past. Now scientists may finally be finding their footing.

doi: 10.1038/d41586-017-08965-0

News & Views


doi: 10.1038/d41586-017-08721-4


doi: 10.1038/d41586-017-08232-2


doi: 10.1038/d41586-017-08755-8


doi: 10.1038/d41586-017-08195-4


doi: 10.1038/d41586-017-08911-0


doi: 10.1038/d41586-017-08652-0



Noble gases trapped in ice cores are used to show that the mean global ocean temperature increased by 2.6 degrees Celsius over the last glacial transition and is closely correlated with Antarctic temperature.

doi: 10.1038/nature25152


In bilaterian animals, the final configurations of central nervous systems seem unrelated to neuroectodermal patterning systems, so it is likely that the various architectures of the ventral nerve cords evolved convergently, many times.

doi: 10.1038/nature25030



Two extremely massive galaxies are seen 800 million years after the Big Bang, showing the rapid growth of early structure and marking the most massive halo known in that era.

doi: 10.1038/nature24629


By implementing a 2D topological charge pump using ultracold bosonic atoms, the theoretically predicted 4D integer quantum Hall effect is confirmed experimentally.

doi: 10.1038/nature25000


A 2D topological charge pump in a photonic waveguide array is used to observe boundary physics associated with the 4D quantum Hall effect experimentally.

doi: 10.1038/nature25011


An approach is developed for the continuous fabrication of lateral multi-junction heterostructures of transition-metal dichalcogenides, in which the sequential formation of heterojunctions is achieved solely by changing the composition of the reactive gas environment in the presence of water vapour.

doi: 10.1038/nature25155


Application of an electric field changes the transport and optical properties of samarium nickelate submerged in water, making it a suitable passive sensor of weak electric fields in salt water.

doi: 10.1038/nature25008


Analyses of potential and actual biomass stocks indicate that trade-offs exist between conserving carbon stocks on managed land and raising the contribution of biomass to raw material and energy supply for the mitigation of climate change.

doi: 10.1038/nature25138


Whole-genome sequencing and comparative genomic analysis of immune-related genes of Cercocebus atys and Macaca mulatta identify candidate genes, such as ICAM2 and TLR4, that may explain the AIDS resistance of C. atys.

doi: 10.1038/nature25140


A parasitic plant produces microRNAs that target host messenger RNAs, causing them to be processed into small interfering RNAs.

doi: 10.1038/nature25027


Heterologous expression of engineered gas vesicles allows noninvasive, deep-tissue ultrasound visualization of engineered bacteria in vivo in mouse tumour models and in the gastrointestinal tract.

doi: 10.1038/nature25021


Abundance of PD-L1, the ligand of the anti-cancer immunotherapy target PD-1, is negatively regulated by poly-ubiquitination via the cyclin D–CDK4/cullin 3–SPOP axis and PD-1 blockade treatment in mice improved survival when combined with CDK4/6 inhibitors.

doi: 10.1038/nature25015


Cellular senescence induced by chemotherapy leads to the acquisition of stemness in cancer cells, which results in enhanced tumour-promoting capacity after forced release or spontaneous escape from the senescent cell-cycle arrest.

doi: 10.1038/nature25167


Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.

doi: 10.1038/nature25169


The crystal structure of the full-length glucagon receptor in complex with a glucagon analogue NNC1702 reveals how the peptide ligand interacts with its target and shows the conformational changes required for receptor activation.

doi: 10.1038/nature25153


The crystal structure of the complement receptor C5aR1 bound to a small-molecule antagonist provides insights into this receptor class and how they could be better targeted therapeutically.

doi: 10.1038/nature25025