p.5
Tracking societal impacts encourages academics to pursue them. The launch of three new Nature journals should also help.doi: 10.1038/d41586-017-08943-6
Volume 553 Issue 7686
리서치 하이라이트
표지 기사： 초음파 리포터 유전자를 이용한 신체 내 미생물의 비침습적 이미지 촬영
최후 빙하기 전환기 동안의 글로벌 평균 해양 온도 분석
좌우대칭 신경 코드의 상시 진화 모델
최초의 10억년 우주 역사에서 거대 헤일로 내에서 성장한 은하계
글로벌 식물 바이오 매스에서 삼림 관리의 예상치 못한 거대 영향
수티망가비 지놈 염기서열을 통한 자연계 SIV 숙주에서의 AIDS 저항성의 원인 파악
새삼류의 마이크로 RNA에 의한 숙주 mRNA 억제
쿨린 3-SPOP를 통한 PD-L1을 불안정화시키는 사이클린 D-CDK4 인산화 효소에 및 이를 통한 암 면역 감시 조절
암 줄기세포화를 촉진하는 재프로그램화와 관련된 염기서열 확인
컨텐츠
Editorial
News
p.9
Neural networks are making biological images easier to process.doi: 10.1038/d41586-018-00004-w
p.10
Silicon Valley philanthropy project revives some grants rejected by a mainstream US biomedical funder.doi: 10.1038/d41586-017-08795-0
p.11
The National Institutes of Health will again fund research that makes viruses more dangerous.doi: 10.1038/d41586-017-08837-7
p.12
Moon missions, ancient genomes and a publishing showdown are set to shape the new year.doi: 10.1038/d41586-018-00009-5
News Features
p.14
Research into this debilitating disease has a rocky past. Now scientists may finally be finding their footing.doi: 10.1038/d41586-017-08965-0
News & Views
p.30
doi: 10.1038/d41586-017-08721-4
p.31
doi: 10.1038/d41586-017-08232-2
p.32
doi: 10.1038/d41586-017-08755-8
p.34
doi: 10.1038/d41586-017-08195-4
p.36
doi: 10.1038/d41586-017-08911-0
p.37
doi: 10.1038/d41586-017-08652-0
Articles
p.39
Noble gases trapped in ice cores are used to show that the mean global ocean temperature increased by 2.6 degrees Celsius over the last glacial transition and is closely correlated with Antarctic temperature.doi: 10.1038/nature25152
p.45
In bilaterian animals, the final configurations of central nervous systems seem unrelated to neuroectodermal patterning systems, so it is likely that the various architectures of the ventral nerve cords evolved convergently, many times.doi: 10.1038/nature25030
Letters
p.51
Two extremely massive galaxies are seen 800 million years after the Big Bang, showing the rapid growth of early structure and marking the most massive halo known in that era.doi: 10.1038/nature24629
p.55
By implementing a 2D topological charge pump using ultracold bosonic atoms, the theoretically predicted 4D integer quantum Hall effect is confirmed experimentally.doi: 10.1038/nature25000
p.59
A 2D topological charge pump in a photonic waveguide array is used to observe boundary physics associated with the 4D quantum Hall effect experimentally.doi: 10.1038/nature25011
p.63
An approach is developed for the continuous fabrication of lateral multi-junction heterostructures of transition-metal dichalcogenides, in which the sequential formation of heterojunctions is achieved solely by changing the composition of the reactive gas environment in the presence of water vapour.doi: 10.1038/nature25155
p.68
Application of an electric field changes the transport and optical properties of samarium nickelate submerged in water, making it a suitable passive sensor of weak electric fields in salt water.doi: 10.1038/nature25008
p.73
Analyses of potential and actual biomass stocks indicate that trade-offs exist between conserving carbon stocks on managed land and raising the contribution of biomass to raw material and energy supply for the mitigation of climate change.doi: 10.1038/nature25138
p.77
Whole-genome sequencing and comparative genomic analysis of immune-related genes of Cercocebus atys and Macaca mulatta identify candidate genes, such as ICAM2 and TLR4, that may explain the AIDS resistance of C. atys.doi: 10.1038/nature25140
p.82
A parasitic plant produces microRNAs that target host messenger RNAs, causing them to be processed into small interfering RNAs.doi: 10.1038/nature25027
p.86
Heterologous expression of engineered gas vesicles allows noninvasive, deep-tissue ultrasound visualization of engineered bacteria in vivo in mouse tumour models and in the gastrointestinal tract.doi: 10.1038/nature25021
p.91
Abundance of PD-L1, the ligand of the anti-cancer immunotherapy target PD-1, is negatively regulated by poly-ubiquitination via the cyclin D–CDK4/cullin 3–SPOP axis and PD-1 blockade treatment in mice improved survival when combined with CDK4/6 inhibitors.doi: 10.1038/nature25015
p.96
Cellular senescence induced by chemotherapy leads to the acquisition of stemness in cancer cells, which results in enhanced tumour-promoting capacity after forced release or spontaneous escape from the senescent cell-cycle arrest.doi: 10.1038/nature25167
p.101
Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.doi: 10.1038/nature25169
p.106
The crystal structure of the full-length glucagon receptor in complex with a glucagon analogue NNC1702 reveals how the peptide ligand interacts with its target and shows the conformational changes required for receptor activation.doi: 10.1038/nature25153
p.111
The crystal structure of the complement receptor C5aR1 bound to a small-molecule antagonist provides insights into this receptor class and how they could be better targeted therapeutically.doi: 10.1038/nature25025
