Science must acknowledge mistakes as it marks its past.
The former physicist shows a welcome immunity to the mood of anti-science resentment that has infected some democracies.
The female bird makes a different and much sneakier sound than the male.
Advance planning has kept some Texas facilities safe during the unprecedented storm.
Rock-encased bone shard left behind by thieves allowed researchers to determine that the remains are probably more than 13,000 years old.
An international partnership seeks African leadership to organize information about the disease.
Researchers deliberately heated up a slice of the Antarctic sea bed to see how ecosystems responded.
Competing spending priorities in the House of Representative and Senate could push funding negotiations into December.
With a national election this month, Germany proves that foresight and stability can power research.
News & Views
Identifying and imaging catalytically active sites on solid surfaces is a grand challenge for science. A microscopy technique has been developed that images 'noise' to detect active sites with nanometre-scale resolution. See Letter p.74
An analysis reveals that both sexual reproduction and early-embryo development in the moss Physcomitrella patens are controlled by cellular calcium influxes through ion-channel proteins. See Letter p.91
High-energy battery electrodes can break apart during operation. Conventional rope-and-pulley systems have inspired the development of a polymer that holds electrodes together at the molecular scale, enabling durable batteries to be made.
Flies use master lists of DNA sequences from transposons to identify and silence these virus-like, genomic parasites. How the lists themselves escape the fate of their transposon targets has now been solved. See Letter p.54
A patient's tumour cells can be transplanted into a mouse to provide a model for analysis and drug testing. A panel of paediatric solid tumour models has been extensively characterized and made freely available. See Letter p.96
Quantum communication offers many advantages over classical methods, but it has been limited to sending signals across a few hundred kilometres. Two studies overcome this limitation. See Article p.43 & Letter p.70
Decoy-state quantum key distribution from a satellite to a ground station is achieved with much greater efficiency than is possible over the same distance using optical fibres.
Commensal bacteria have N-acyl amide synthase genes that encode signalling molecules (N-acyl amides) that can interact with G-protein-coupled receptors and elicit host cellular responses similar to eukaryotic N-acyl amides.
Transcription of Drosophila PIWI-interacting RNA (piRNA) clusters is enforced through RNA polymerase II pre-initiation complex formation within repressive heterochromatin, accomplished through the transcription factor IIA subunit paralogue Moonshiner.
The structures of AMPA receptors in complex with auxiliary proteins are resolved by cryo-electron microscopy, and reveal conformational and permeation pathway changes that are associated with activation and desensitization of ionotropic glutamate receptors.
The process that generates Earth’s most intense aurora is found to occur at Jupiter, but is of only secondary importance in generating Jupiter’s much more powerful aurora.
Quantum teleportation of single-photon qubits from a ground observatory to a satellite in low-Earth orbit via an uplink channel is achieved with a fidelity that is well above the classical limit.
Scanning tunnelling microscopy is used to distinguish between different active sites of a catalyst—such as boundaries between different materials—during a reaction, allowing the contributions of these sites to be evaluated.
Metal complexes of the pentazole anion exhibit multiple coordination modes, through ionic, covalent and hydrogen-bonding interactions, and good thermal stability with onset decomposition temperatures greater than 100 °C.
On marine islands, most species are good dispersers and most niches are filled by immigration with little adaptive radiation; speciation increases over time, associated with the arrival of weak dispersers that randomly establish isolated populations.
Two parallel signalling pathways, driven by Nodal and BMP, respectively integrate left- and right-handed information that drives heart looping and morphogenesis, and are conserved between zebrafish, chicken and mouse.
Mutations in genes that encode GLUTAMTATE RECEPTOR-LIKE (GLR) channels in the moss Physcomitrella patens result in failure of motile sperm to target the female reproductive organs and of zygotes to develop properly.
A protocol producing orthotopic patient-derived xenografts at diagnosis, recurrence, and autopsy demonstrates proof of principle for using these tumours for basic and translational research on paediatric solid tumours.
CMTM6 maintains PD-L1 at the plasma membrane by inhibiting its lysosome-mediated degradation and promoting its recycling.
CMTM6 and CMTM4 bind to and stabilize the inhibitory receptor PD-L1 and regulate PD-L1 levels at the surface of human tumour and immune cells.
The authors use tiled CRISPR activation for functional enhancer discovery across two autoimmunity risk loci, CD69 and IL2RA, and identify elements with features of stimulus-responsive enhancers, including an IL2RA enhancer that harbours a fine-mapped autoimmunity risk variant.