p.5
Science must acknowledge mistakes as it marks its past.doi: 10.1038/549005b
Volume 549 Issue 7670
Editorials
p.5
The former physicist shows a welcome immunity to the mood of anti-science resentment that has infected some democracies.doi: 10.1038/549005a
p.6
The female bird makes a different and much sneakier sound than the male.doi: 10.1038/549006a
News
p.13
Advance planning has kept some Texas facilities safe during the unprecedented storm.doi: 10.1038/nature.2017.22542
p.14
Rock-encased bone shard left behind by thieves allowed researchers to determine that the remains are probably more than 13,000 years old.doi: 10.1038/nature.2017.22521
p.15
An international partnership seeks African leadership to organize information about the disease.doi: 10.1038/nature.2017.22545
p.16
Researchers deliberately heated up a slice of the Antarctic sea bed to see how ecosystems responded.doi: 10.1038/nature.2017.22543
p.17
Competing spending priorities in the House of Representative and Senate could push funding negotiations into December.doi: 10.1038/nature.2017.22548
News Features
p.18
With a national election this month, Germany proves that foresight and stability can power research.doi: 10.1038/549018a
News & Views
p.34
Identifying and imaging catalytically active sites on solid surfaces is a grand challenge for science. A microscopy technique has been developed that images 'noise' to detect active sites with nanometre-scale resolution. See Letter p.74doi: 10.1038/549034a
p.35
An analysis reveals that both sexual reproduction and early-embryo development in the moss Physcomitrella patens are controlled by cellular calcium influxes through ion-channel proteins. See Letter p.91doi: 10.1038/nature23543
p.37
High-energy battery electrodes can break apart during operation. Conventional rope-and-pulley systems have inspired the development of a polymer that holds electrodes together at the molecular scale, enabling durable batteries to be made.doi: 10.1038/549037a
p.38
Flies use master lists of DNA sequences from transposons to identify and silence these virus-like, genomic parasites. How the lists themselves escape the fate of their transposon targets has now been solved. See Letter p.54doi: 10.1038/549038a
p.39
A patient's tumour cells can be transplanted into a mouse to provide a model for analysis and drug testing. A panel of paediatric solid tumour models has been extensively characterized and made freely available. See Letter p.96doi: 10.1038/nature23545
p.41
Quantum communication offers many advantages over classical methods, but it has been limited to sending signals across a few hundred kilometres. Two studies overcome this limitation. See Article p.43 & Letter p.70doi: 10.1038/549041a
Articles
p.43
Decoy-state quantum key distribution from a satellite to a ground station is achieved with much greater efficiency than is possible over the same distance using optical fibres.doi: 10.1038/nature23655
p.48
Commensal bacteria have N-acyl amide synthase genes that encode signalling molecules (N-acyl amides) that can interact with G-protein-coupled receptors and elicit host cellular responses similar to eukaryotic N-acyl amides.doi: 10.1038/nature23874
p.54
Transcription of Drosophila PIWI-interacting RNA (piRNA) clusters is enforced through RNA polymerase II pre-initiation complex formation within repressive heterochromatin, accomplished through the transcription factor IIA subunit paralogue Moonshiner.doi: 10.1038/nature23482
p.60
The structures of AMPA receptors in complex with auxiliary proteins are resolved by cryo-electron microscopy, and reveal conformational and permeation pathway changes that are associated with activation and desensitization of ionotropic glutamate receptors.doi: 10.1038/nature23479
Letters
p.66
The process that generates Earth’s most intense aurora is found to occur at Jupiter, but is of only secondary importance in generating Jupiter’s much more powerful aurora.doi: 10.1038/nature23648
p.70
Quantum teleportation of single-photon qubits from a ground observatory to a satellite in low-Earth orbit via an uplink channel is achieved with a fidelity that is well above the classical limit.doi: 10.1038/nature23675
p.74
Scanning tunnelling microscopy is used to distinguish between different active sites of a catalyst—such as boundaries between different materials—during a reaction, allowing the contributions of these sites to be evaluated.doi: 10.1038/nature23661
p.78
Metal complexes of the pentazole anion exhibit multiple coordination modes, through ionic, covalent and hydrogen-bonding interactions, and good thermal stability with onset decomposition temperatures greater than 100 °C.doi: 10.1038/nature23662
p.82
On marine islands, most species are good dispersers and most niches are filled by immigration with little adaptive radiation; speciation increases over time, associated with the arrival of weak dispersers that randomly establish isolated populations.doi: 10.1038/nature23680
p.86
Two parallel signalling pathways, driven by Nodal and BMP, respectively integrate left- and right-handed information that drives heart looping and morphogenesis, and are conserved between zebrafish, chicken and mouse.doi: 10.1038/nature23454
p.91
Mutations in genes that encode GLUTAMTATE RECEPTOR-LIKE (GLR) channels in the moss Physcomitrella patens result in failure of motile sperm to target the female reproductive organs and of zygotes to develop properly.doi: 10.1038/nature23478
p.96
A protocol producing orthotopic patient-derived xenografts at diagnosis, recurrence, and autopsy demonstrates proof of principle for using these tumours for basic and translational research on paediatric solid tumours.doi: 10.1038/nature23647
p.101
CMTM6 maintains PD-L1 at the plasma membrane by inhibiting its lysosome-mediated degradation and promoting its recycling.doi: 10.1038/nature23643
p.106
CMTM6 and CMTM4 bind to and stabilize the inhibitory receptor PD-L1 and regulate PD-L1 levels at the surface of human tumour and immune cells.doi: 10.1038/nature23669
p.111
The authors use tiled CRISPR activation for functional enhancer discovery across two autoimmunity risk loci, CD69 and IL2RA, and identify elements with features of stimulus-responsive enhancers, including an IL2RA enhancer that harbours a fine-mapped autoimmunity risk variant.doi: 10.1038/nature23875
