Volume 549 Issue 7670



Science must acknowledge mistakes as it marks its past.

doi: 10.1038/549005b


The former physicist shows a welcome immunity to the mood of anti-science resentment that has infected some democracies.

doi: 10.1038/549005a


The female bird makes a different and much sneakier sound than the male.

doi: 10.1038/549006a



Advance planning has kept some Texas facilities safe during the unprecedented storm.

doi: 10.1038/nature.2017.22542


Rock-encased bone shard left behind by thieves allowed researchers to determine that the remains are probably more than 13,000 years old.

doi: 10.1038/nature.2017.22521


An international partnership seeks African leadership to organize information about the disease.

doi: 10.1038/nature.2017.22545


Researchers deliberately heated up a slice of the Antarctic sea bed to see how ecosystems responded.

doi: 10.1038/nature.2017.22543


Competing spending priorities in the House of Representative and Senate could push funding negotiations into December.

doi: 10.1038/nature.2017.22548

News Features


With a national election this month, Germany proves that foresight and stability can power research.

doi: 10.1038/549018a

News & Views


Identifying and imaging catalytically active sites on solid surfaces is a grand challenge for science. A microscopy technique has been developed that images 'noise' to detect active sites with nanometre-scale resolution. See Letter p.74

doi: 10.1038/549034a


An analysis reveals that both sexual reproduction and early-embryo development in the moss Physcomitrella patens are controlled by cellular calcium influxes through ion-channel proteins. See Letter p.91

doi: 10.1038/nature23543


High-energy battery electrodes can break apart during operation. Conventional rope-and-pulley systems have inspired the development of a polymer that holds electrodes together at the molecular scale, enabling durable batteries to be made.

doi: 10.1038/549037a


Flies use master lists of DNA sequences from transposons to identify and silence these virus-like, genomic parasites. How the lists themselves escape the fate of their transposon targets has now been solved. See Letter p.54

doi: 10.1038/549038a


A patient's tumour cells can be transplanted into a mouse to provide a model for analysis and drug testing. A panel of paediatric solid tumour models has been extensively characterized and made freely available. See Letter p.96

doi: 10.1038/nature23545


Quantum communication offers many advantages over classical methods, but it has been limited to sending signals across a few hundred kilometres. Two studies overcome this limitation. See Article p.43 & Letter p.70

doi: 10.1038/549041a



Decoy-state quantum key distribution from a satellite to a ground station is achieved with much greater efficiency than is possible over the same distance using optical fibres.

doi: 10.1038/nature23655


Commensal bacteria have N-acyl amide synthase genes that encode signalling molecules (N-acyl amides) that can interact with G-protein-coupled receptors and elicit host cellular responses similar to eukaryotic N-acyl amides.

doi: 10.1038/nature23874


Transcription of Drosophila PIWI-interacting RNA (piRNA) clusters is enforced through RNA polymerase II pre-initiation complex formation within repressive heterochromatin, accomplished through the transcription factor IIA subunit paralogue Moonshiner.

doi: 10.1038/nature23482


The structures of AMPA receptors in complex with auxiliary proteins are resolved by cryo-electron microscopy, and reveal conformational and permeation pathway changes that are associated with activation and desensitization of ionotropic glutamate receptors.

doi: 10.1038/nature23479



The process that generates Earth’s most intense aurora is found to occur at Jupiter, but is of only secondary importance in generating Jupiter’s much more powerful aurora.

doi: 10.1038/nature23648


Quantum teleportation of single-photon qubits from a ground observatory to a satellite in low-Earth orbit via an uplink channel is achieved with a fidelity that is well above the classical limit.

doi: 10.1038/nature23675


Scanning tunnelling microscopy is used to distinguish between different active sites of a catalyst—such as boundaries between different materials—during a reaction, allowing the contributions of these sites to be evaluated.

doi: 10.1038/nature23661


Metal complexes of the pentazole anion exhibit multiple coordination modes, through ionic, covalent and hydrogen-bonding interactions, and good thermal stability with onset decomposition temperatures greater than 100 °C.

doi: 10.1038/nature23662


On marine islands, most species are good dispersers and most niches are filled by immigration with little adaptive radiation; speciation increases over time, associated with the arrival of weak dispersers that randomly establish isolated populations.

doi: 10.1038/nature23680


Two parallel signalling pathways, driven by Nodal and BMP, respectively integrate left- and right-handed information that drives heart looping and morphogenesis, and are conserved between zebrafish, chicken and mouse.

doi: 10.1038/nature23454


Mutations in genes that encode GLUTAMTATE RECEPTOR-LIKE (GLR) channels in the moss Physcomitrella patens result in failure of motile sperm to target the female reproductive organs and of zygotes to develop properly.

doi: 10.1038/nature23478


A protocol producing orthotopic patient-derived xenografts at diagnosis, recurrence, and autopsy demonstrates proof of principle for using these tumours for basic and translational research on paediatric solid tumours.

doi: 10.1038/nature23647


CMTM6 maintains PD-L1 at the plasma membrane by inhibiting its lysosome-mediated degradation and promoting its recycling.

doi: 10.1038/nature23643


CMTM6 and CMTM4 bind to and stabilize the inhibitory receptor PD-L1 and regulate PD-L1 levels at the surface of human tumour and immune cells.

doi: 10.1038/nature23669


The authors use tiled CRISPR activation for functional enhancer discovery across two autoimmunity risk loci, CD69 and IL2RA, and identify elements with features of stimulus-responsive enhancers, including an IL2RA enhancer that harbours a fine-mapped autoimmunity risk variant.

doi: 10.1038/nature23875