Editorials
From avalanches to pharmaceuticals, the physics of powders relies on a much-maligned talent.
doi: 10.1038/546575b
Researchers and journals need to do more to counter inapropriately manipulated figures in science.
doi: 10.1038/546575a
The highest-earning academics aren’t necessarily those who do the most research.
doi: 10.1038/546576a
News
Technology far exceeded expectations in LISA Pathfinder test.
doi: 10.1038/546583a
Justices overturn lower-court rulings on policy targeting people from six majority-Muslim countries.
doi: 10.1038/nature.2017.22190
Errors could cause researchers to overestimate the rate of photosynthesis when water is scarce.
doi: 10.1038/546585a
Lethal effects from pulses of sound used to probe the sea floor can travel over a kilometre.
doi: 10.1038/nature.2017.22167
Engineered microbes turn a bacterium's immune response against itself using CRISPR.
doi: 10.1038/nature.2017.22173
News Features
Logic-defying experiments in quantum causality can twist the notion of time itself.
doi: 10.1038/546590a
News & Views
Quantum objects that can hold more information than quantum bits have been generated and manipulated in an integrated photonic platform, paving the way for advanced protocols in quantum information processing. See Letter p.622
doi: 10.1038/546602a
Most human infectious diseases are initially transmitted from animals. An analysis of all known mammalian viruses improves our understanding of such cross-species spillover, with potential benefits for public health. See Letter p.646
doi: 10.1038/nature23088
A polymer that incorporates liquid-crystal components generates continuous mechanical waves when lit by ultraviolet light, with potential applications for energy harvesting and self-cleaning surfaces. See Letter p.632
doi: 10.1038/546604a
Intestinal infection with rotavirus is a major cause of diarrhoea in infants, and can be fatal. The identification of immune sensor proteins that detect and restrict this viral infection now illuminates the body's defence system. See Letter p.667
doi: 10.1038/nature23090
Small changes to molecular structures can transform how reactions occur, but studying reaction mechanisms directly is difficult. An imaging technique that provides direct insights into competing mechanisms might improve matters.
doi: 10.1038/546608a
Intestinal infection with rotavirus is a major cause of diarrhoea in infants, and can be fatal. The identification of immune sensor proteins that detect and restrict this viral infection now illuminates the body's defence system. See Letter p.667
doi: 10.1038/546609a
Articles
A combination of microprism-based cellular imaging to monitor insular cortex visual cue responses in behaving mice across hunger states with circuit mapping and manipulations reveals a neural basis for state-specific biased processing of motivationally relevant cues.
doi: 10.1038/nature22375
The cryo-electron microscopy structure of the yeast spliceosome in a pre-catalytic state provides insights into the molecular events leading to formation of the spliceosome active site.
doi: 10.1038/nature22799
Letters
The on-chip generation of high-dimensional frequency-entangled states and their spectral-domain manipulation are demonstrated, introducing a powerful and practical platform for quantum information processing.
doi: 10.1038/nature22986
A new type of fermion, corresponding to a three-fold degeneracy in the electronic band structure of crystalline molybdenum phosphide, is observed, which lies conceptually between Dirac and Weyl fermions.
doi: 10.1038/nature22390
Illumination of thin liquid-crystal polymer films that contain azobenzene derivatives with short thermal relaxation times induces a continuous wave motion throughout the films, owing to a feedback loop driven by material self-shadowing.
doi: 10.1038/nature22987
A phase-separation mechanism is proposed for the dominance of the surface tension effect over the solute effect in the observed activation of ultrafine cloud condensation nuclei.
doi: 10.1038/nature22806
Detailed micro-computed tomography analysis of the skull of Lethiscus stocki places it much earlier in the tetrapod lineage that was previously thought, showing that early tetrapods were more morphologically diverse than has been believed.
doi: 10.1038/nature22966
Analysis of a comprehensive database of mammalian host–virus relationships reveals that both the total number of viruses that infect a given species and the proportion likely to be zoonotic are predictable and that this enables identification of mammalian species and geographic locations where novel zoonoses are likely to be found.
doi: 10.1038/nature22975
The poxvirus vaccinia virus phosphorylates serine/threonine residues in the human small ribosomal subunit RACK1, converting it to a plant-like state to favour translation of poxvirus mRNAs
doi: 10.1038/nature22814
Genetic studies have shown the association of Parkinson’s disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson’s disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson’s disease. These responses may explain the association of Parkinson’s disease with specific major histocompatibility complex alleles.
doi: 10.1038/nature22815
Prenatal immune suppression is regulated by fetal arginase-2-expressing dendritic cells which respond normally to toll-like receptor stimulation but, in contrast to adult dendritic cells, induce regulatory T cells and repress TNF-α secretion by effector T cells.
doi: 10.1038/nature22795
The inflammasome receptor Nlrp9b defends against enteric viruses by interacting with double-stranded viral RNA-bound helicase Dhx9, triggering gasdermin-D-dependent pyroptotic cell death of infected cells and secretion of Il-18.
doi: 10.1038/nature22967
In prostate cancer, the oncogenicity of transcription factor ERG is mediated, in part, by competition with another member of the ETS family, ERF.
doi: 10.1038/nature22820
Genetically engineered ‘lymphoreporter’ mouse strains are used to track melanoma dissemination in vivo, identifying midkine as a tumour-secreted factor that acts at a distance, preparing pre-metastatic niches and serving as an indicator of poor prognosis in patients.
doi: 10.1038/nature22977
The crystal structure of the bacterial potassium import complex KdpFABC shows how ATP hydrolysis is coupled to potassium transport to maintain cellular homeostasis under low potassium conditions.
doi: 10.1038/nature22970