Editorials
Researchers must seize the chance to inject scientific sense into US governance of modified crops and livestock.
doi: 10.1038/546327b
Governments, funders and scientific communities must move beyond lip-service and commit to data-sharing practices and platforms.
doi: 10.1038/546327a
Brazil and neighbouring nations need a transparent and integrated energy assessment centred on evidence.
doi: 10.1038/546328a
News
Human fetuses have an immune system that acts differently from the adult version.
doi: 10.1038/546335a
Conservative party loses majority but aims to form government.
doi: 10.1038/nature.2017.22138
US vice-president to head group overseeing civilian and military space activities.
doi: 10.1038/nature.2017.22130
Analysis reveals that the number of clinical trials funded by the National Institute of Mental Health has fallen by 45% since the agency began to focus on the biological roots of disease.
doi: 10.1038/546338a
Finding could help researchers to better predict where these viruses are likely to make the jump from animals to people.
doi: 10.1038/nature.2017.22137
News Features
Machine-learning project will analyse 1,000 years of maps and manuscripts from the floating city's golden age.
doi: 10.1038/546341a
News & Views
Most state-of-the-art methods of wireless energy delivery are inherently limited to static devices. An approach based on fundamental physics could overcome this limitation, opening up a wealth of applications. See Letter p.387
doi: 10.1038/546354a
Evolutionary trees constructed using both newly sequenced and previously available Zika virus genomes reveal how the recent outbreak arose in Brazil and spread across the Americas. See Letters p.401, p.406 & p.411
doi: 10.1038/nature22495
Cell division requires the action of key regulator proteins called cyclins and CDKs. It emerges that a cyclin–CDK complex can regulate cell metabolism, and targeting this metabolic regulation causes tumour regression in mice. See Letter p.426
doi: 10.1038/nature22504
Rubber sheets that reversibly bind and release substrates have been made by copying a subtlety in the shape of octopus suckers. The findings reveal how macro-scale biological structures can influence function. See Letter p.396
doi: 10.1038/546358a
A paper that analysed genetic variants in 14,000 people to identify disease-associated regions set the standard for collaborative genome-wide association studies and provided methodological advances whose effects are still felt today.
doi: 10.1038/546360a
Production of the metabolite acetyl-CoA near specific regions of DNA modulates gene expression in mouse neurons during cellular differentiation and memory formation. See Article p.381
doi: 10.1038/nature22498
Perspective
doi: 10.1038/nature22333
Articles
Genetic and phenotypic analysis reveals expression quantitative trait loci in human induced pluripotent stem cell lines associated with cancer and disease.
doi: 10.1038/nature22403
The establishment of a drug-discovery screening pipeline for cryptosporidiosis, and identification of pyrazolopyridines as selective ATP-competitive inhibitors of the Cryptosporidium lipid kinase PI(4)K.
doi: 10.1038/nature22337
The metabolic enzyme acetyl coenzyme A synthetase directly regulates gene expression during memory formation by binding to specific genes and providing acetyl coenzyme A for histone acetylation.
doi: 10.1038/nature22405
Letters
A nonlinear parity–time-symmetric circuit is used to enable robust wireless power transfer to a moving device over a distance of one metre without the need for tuning.
doi: 10.1038/nature22404
Molecular dynamics simulations of the Pb(Mg1/3,Nb2/3)O3–PbTiO3 relaxor reveal a multi-domain state analogous to the slush state of water that provides an explanation for the unusual properties of relaxors.
doi: 10.1038/nature22068
The suction cups found in octopus tentacles are the inspiration for a synthetic adhesive that functions well in dry and wet conditions and is resistant to chemical contamination.
doi: 10.1038/nature22382
Genome sequencing of Zika virus samples from infected patients and Aedes aegypti mosquitoes in Florida shows that the virus was probably introduced into the United States on multiple occasions, and that the Caribbean is the most likely source.
doi: 10.1038/nature22400
Virus genomes reveal the establishment of Zika virus in Brazil and the Americas, and provide an appropriate timeframe for baseline (pre-Zika) microcephaly in different regions.
doi: 10.1038/nature22401
One hundred and ten Zika virus genomes from ten countries and territories involved in the Zika virus epidemic reveal rapid expansion of the epidemic within Brazil and multiple introductions to other regions.
doi: 10.1038/nature22402
The authors trace the emergence of porcine primordial germ cells and develop in vitro models of primordial germ cell development from human and monkey pluripotent stem cells in order to provide insight into early human development.
doi: 10.1038/nature22812
Regulatory T cells expressing the transcription factor T-bet selectively suppress TH1 and CD8 T cells, but not TH2 or TH17 activation and associated autoimmunity.
doi: 10.1038/nature22360
The cyclin D3–CDK6 kinase complex, which is overactive in some cancers, inhibits two key glycolysis enzymes and thereby enhances the levels of antioxidants in cells, promoting tumour cell survival.
doi: 10.1038/nature22797
Through drug exposure, a rare, transient transcriptional program characterized by high levels of expression of known resistance drivers can get ‘burned in’, leading to the selection of cells endowed with a transcriptional drug resistance and thus more chemoresistant cancers.
doi: 10.1038/nature22794
The structure of the anti-CRISPR protein AcrIIA4, in complex with a single-guide RNA and Cas9, reveals that the protein inhibits DNA binding and blocks the Cas9 endonuclease active site.
doi: 10.1038/nature22377