Volume 544 Issue 7650

Editorials

News

News Features

News & Views

In peril from a perfect pathogen p.300

It emerges that a fungal infection killing salamanders has many potential reservoirs, and that environmentally resistant spores transmit disease. Urgent interventions are needed to save susceptible populations from extinction. See Letter p.353

doi: 10.1038/544300a

Crystals aligned through graphene p.301

Graphene has been used as a 'transparent' layer that allows single crystals of a material to be grown on a substrate, and then lifted off — in much the same way that baking paper lets cakes be removed easily from tins. See Letter p.340

doi: 10.1038/544301a

Two–for–one on potential therapies p.302

Molecules that inhibit the synthesis of the ataxin 2 protein can ameliorate the effects of two neurodegenerative diseases in mouse models, raising hopes for the success of this approach in clinical trials. See Letters p.362 & p.367

doi: 10.1038/nature21911

Gut microbes augment neurodegeneration p.304

Bacterial residents of the human body often provide beneficial effects, but some can be harmful. The action of gut bacteria has been found to be tightly linked to neurodegeneration in a mouse model of Parkinson's disease.

doi: 10.1038/nature21910

Ice-shelf stability questioned p.306

Surface lakes and streams are forming on Antarctica's ice shelves, making them susceptible to instability and possible collapse. But rivers could mitigate this effect by efficiently exporting meltwater to the ocean. See Letters p.344 & p.349

doi: 10.1038/544306a

A receptor that might block itself p.307

The structure of the angiotensin II type 2 receptor reveals a potential mode of self-blocking action. This might explain its lack of signalling, and opens up avenues of investigation into its function and role in disease. See Article p.327

doi: 10.1038/nature21907

Articles

Letters

Rad51-mediated double-strand break repair and mismatch correction of divergent substrates p.377

DNA repair by break-induced replication begins with the Rad51-mediated invasion of single-stranded DNA into a double-stranded donor template; this study shows that successful recombination between highly mismatched substrates can occur when only five consecutive bases can be paired and that mismatch correction is most efficient near the invading end of the recipient strand.

doi: 10.1038/nature22046