The US president’s approval of a controversial oil pipeline offers a disturbing glimpse of the future. But he will struggle to get things all his own way.
The country may lift its ban on the analysis of gene-coding regions in DNA samples.
The most vulnerable cancer patients are drawing the attention they deserve.
Physicists try to rebuild the laws of heat and energy for processes at a quantum scale.
Emphasis on innovation overshadowed by funding freeze for key research councils.
Global health charity is latest funder to start its own publishing ‘channel’ — and the European Commission is considering its own service.
The months between the Brexit vote and this week's triggering of Article 50 have been a turbulent time for scientists — and things show no sign of calming.
Gut bacteria and altered metabolic pathways are suspects in mysterious disease.
Ichthyosaurs were some of the largest and most mysterious predators to ever prowl the oceans. Now they are giving up their secrets.
Epigenetic discoveries are fuelling renewed interest in the fusion proteins that have bedevilled cancer biologists.
News & Views
Stem-cell divisions are thought to be essential to tumour growth. Targeted removal of a specific stem-cell population reveals its role in tumour development and in the growth of tumours formed by cell migration to distant sites. See Article p.676
An iron complex has been made that has a long-lived excited state and emits light at room temperature as a result of a charge-transfer process. This breakthrough might allow the production of cheap solar cells. See Letter p.695
The cell divisions that occur when a larva develops into an adult Caenorhabditis elegans worm were described in a cell-lineage map in 1977. The work has provided the foundation for many discoveries about developmental mechanisms.
Marine protected areas are being implemented at an accelerating pace, and hold promise for restoring damaged ecosystems. But glaring shortfalls in staffing and funding often lead to suboptimal outcomes. See Article p.665
Subpopulations of neurons fire at specific geographical locations, providing a mental map of an animal's position in space. The finding that the circuitry can also support auditory maps sheds light on the neuronal structure of cognition. See Letter p.719
Do human consumption habits affect groundwater depletion as a result of international food trade? A global analysis indicates that they do, and shows which products and countries have the biggest impact. See Letter p.700
Modification of methyl groups attached to DNA alters gene expression, and mutations that deregulate this methylation are common in some leukaemias. Drugs that target aberrant methylation are emerging as promising therapeutics.
Planets and most asteroids revolve around the Sun in the same direction. But an asteroid that shares Jupiter's orbit has been revolving in the opposite direction for about a million years. See Letter p.687
Energy–structure–function maps that describe the possible structures and properties of molecular crystals are developed, and these maps are used to guide the experimental discovery of porous materials with specific functions.
Although 71% of marine protected areas are benefiting fish populations, their effects are highly variable, with staff capacity proving to be the most important explanatory variable.
Use of a head-mounted miniature microscope in awake, behaving mice reveals that neural ensembles in the basal and lateral amygdala encode associations between conditioned and unconditioned stimuli in a way that matches models of supervised learning.
Ablation of Lgr5+ cancer stem cells does not result in regression of primary colorectal tumours, but prevents the formation and maintenance of metastasis in the liver.
LACTB modulates mitochondrial lipid metabolism and changes the differentiation state of breast cancer cells, thereby negatively affecting the growth of various tumorigenic, but not non-tumorigenic, cells both in vitro and in vivo.
Asteroid 2015 BZ509 is a retrograde co-orbital asteroid of the planet Jupiter, stably orbiting in a sense opposite to that of Jupiter’s orbit around the Sun for around a million years.
A direct synthesis of high-aspect-ratio microporous zeolite nanosheets and the use of such nanosheets in separation membranes are described.
Transition-metal complexes are used as photosensitizers, in light-emitting diodes, for biosensing and in photocatalysis. A key feature in these applications is excitation from the ground state to a charge-transfer state; the long charge-transfer-state lifetimes typical for complexes of ruthenium and other precious metals are often essential to ensure high performance. There is much interest in replacing these scarce elements with Earth-abundant metals, with iron and copper being particularly attractive owing to their low cost and non-toxicity. But despite the exploration of innovative molecular designs, it remains a formidable scientific challenge to access Earth-abundant transition-metal complexes with long-lived charge-transfer excited states. No known iron complexes are considered photoluminescent at room temperature, and their rapid excited-state deactivation precludes their use as photosensitizers. Here we present the iron complex [Fe(btz)3]3+ (where btz is 3,3′-dimethyl-1,1′-bis(p-tolyl)-4,4′-bis(1,2,3-triazol-5-ylidene)), and show that the superior σ-donor and π-acceptor electron properties of the ligand stabilize the excited state sufficiently to realize a long charge-transfer lifetime of 100 picoseconds (ps) and room-temperature photoluminescence. This species is a low-spin Fe(iii) d5 complex, and emission occurs from a long-lived doublet ligand-to-metal charge-transfer (2LMCT) state that is rarely seen for transition-metal complexes. The absence of intersystem crossing, which often gives rise to large excited-state energy losses in transition-metal complexes, enables the observation of spin-allowed emission directly to the ground state and could be exploited as an increased driving force in photochemical reactions on surfaces. These findings suggest that appropriate design strategies can deliver new iron-based materials for use as light emitters and photosensitizers.
Global food consumption drives irrigation for crops, which depletes aquifers in some regions; here we quantify the volumes of groundwater depletion associated with global food production and international trade.
The transboundary health impacts of air pollution associated with the international trade of goods and services are greater than those associated with long-distance atmospheric pollutant transport.
A geologically informed model of the relationship between changing island area and species richness for the Hawaiian archipelago reveals the rates of species richness change for 14 endemic groups over their entire evolutionary histories without the need for fossil data or molecular phylogenies.
Whole-genome sequencing of normal blood cells sampled from 241 adults is used to infer mosaic point mutations that are likely to have arisen during early embryogenesis, providing insight into how early cellular dynamics may affect adult tissues.
Cells in the hippocampal–entorhinal circuit, which fire in response to navigational variables such as location or speed, are shown also to encode continuous, task-relevant but non-spatial variables such as sound frequency.
Evidence for the abundant presentation of class II neoantigens by a human B-cell lymphoma.
A new chimaeric mouse model of metastatic castration-resistant prostate cancer to efficiently test combination therapies in an autochthonous setting.
The selective allosteric ABL1 inhibitor ABL001 (asciminib) represents a new inhibitory mechanism for BCR–ABL1-driven malignancies, and its efficacy and evolving mechanisms of resistance do not overlap with those of other BCR–ABL1 kinase inhibitors.
Double electron–electron resonance and computer simulations are used to describe conformational dynamics in the ATP-binding cassette transporter Pgp, which has an important role in the clearance of xenobiotics and cancer resistance to chemotherapy.