p.287
As the Great Barrier Reef suffers yet more potentially fatal damage, it makes no sense to chop funds from a global progamme that analyses the threats of a changing climatedoi: 10.1038/543287a
Volume 543 Issue 7645
리서치 하이라이트
표지 기사： 대보초의 백화현상과 글로벌 기후 변화
환경적으로 지속 가능한 발전을 유도하는 미네랄 공급 방식
자궁경부암에 대한 지놈 및 분자 생물학적 특성 분석
연골 어류에서의 전기 신호 감지와 관련된 분자생물학적 기초 분석
수백억년 전 은하계 형성이 가장 활성화된 시기에 은하계 디스크에서 우점했던 바리온
반도체 칩 회로에 대한 고 해상도 비파과성 3차원 이미지 촬영 기술
바이오 연료를 이용한 항공기 미세 먼지 방출 감소 효과
고원생대 스테롤 생합성과 산소량 증가 간의 상관관계
항암 대식세포를 통해 유방암에 대한 항암효과 및 전이를 억제하는 제 IIa형 HDAC 억제제
컨텐츠
Editorials
p.288
The Nature journals continue journey towards greater rigour.doi: 10.1038/543288b
p.288
A British Library collection of regional words and phrases shows that language is still evolving.doi: 10.1038/543288a
News
p.295
Geologists unearth signs of major volcanic events stretching back 3 billion years.doi: 10.1038/543295a
p.296
University takes on US National Institutes of Health over animals used for Alzheimer’s research.doi: 10.1038/nature.2017.21620
p.297
A rare find in land animals reveals a new way to glow.doi: 10.1038/nature.2017.21616
p.298
To work out how the yeast genome evolved, bioengineers are recreating it.doi: 10.1038/nature.2017.21615
p.299
Hundreds of researchers pick through clinical trial from a major blood-pressure study, to the dismay of some who collected the information.doi: 10.1038/nature.2017.21572
p.300
The massive project will intercept γ-ray showers in an unexplored energy band.doi: 10.1038/543300a
News Features
p.302
Agricultural scientists look beyond synthetic chemistry to battle pesticide resistance.doi: 10.1038/543302a
p.306
Oil palm has a reputation as an environmental menace. Can the latest genetic research change that?doi: 10.1038/543306a
News & Views
p.318
The masses of nearby spiral galaxies are dominated by invisible 'dark matter'. Surprisingly, galaxies in the distant Universe seem to contain comparatively little of it. See Letter p.397doi: 10.1038/543318a
p.319
Surgical repair of a detached retina involves the injection of a gas or silicone oil into the eye to hold the retina in place. The development of a gel with more-desirable properties than these substances might improve the success of this procedure.doi: 10.1038/nature21898
p.320
The glycoprotein lipocalin 2 is released from the bones of mice in a nutrient-dependent manner and binds to receptors in the brain to suppress appetite. This is the first example of bone-derived signals mediating hunger. See Article p.385doi: 10.1038/nature21501
p.322
A global analysis finds that nitrogen fertilizers could be used more efficiently if their international distribution across croplands was altered — a measure that would also decrease nitrogen pollution.doi: 10.1038/543322a
p.323
doi: 10.1038/543323a
p.324
Aggregates are aberrant, non-functional forms of protein that often build up in cells in response to stress. Organelles called mitochondria have now been found to be active players in the clearance of these protein aggregates. See Letter p.443doi: 10.1038/nature21892
p.325
doi: 10.1038/543325a
p.325
The cellular response to low oxygen levels is regulated by a process in which one protein is ousted from a binding site by another. It emerges that protein disorder allows the displacement to occur remarkably efficiently. See Letter p.447doi: 10.1038/nature21893
Perspective
p.367
doi: 10.1038/nature21359
Articles
p.373
Aerial and underwater survey data combined with satellite-derived measurements of sea surface temperature over the past two decades show that multiple mass-bleaching events have expanded to encompass virtually all of the Great Barrier Reef.doi: 10.1038/nature21707
p.378
This paper describes molecular subtypes of cervical cancers, including squamous cell carcinoma and adenocarcinoma clusters defined by HPV status and molecular features, and distinct molecular pathways that are activated in cervical carcinomas caused by different somatic alterations and HPV types.doi: 10.1038/nature21386
p.385
Osteoblast-derived LCN2 activates the melanocortin 4 receptor in neurons of the paraventricular nucleus of the hypothalamus to suppress appetite, regulates insulin secretion and increases insulin sensitivity and glucose tolerance.doi: 10.1038/nature21697
p.391
Detection of weak electrical signals by skates relies on functional coupling of specific calcium and potassium channels, which mediates oscillations in electrosensory cell membrane voltage.doi: 10.1038/nature21401
Letters
p.397
The rotation velocities in the outer disks of six massive star-forming galaxies are shown to decrease with disk radius, owing to high baryonic mass fractions and large velocity dispersions.doi: 10.1038/nature21685
p.402
A recently developed computational imaging technique, X-ray ptychographic tomography, is used to study integrated circuits, and a 3D image of a processor chip with a resolution of 14.6 nm is obtained.doi: 10.1038/nature21698
p.407
Synthetic hydrogels are here created by enzyme-induced mineralization of hydrogel networks, yielding materials that are tough yet impressively stiff, with calcium phosphate particles distributed homogeneously throughout the network.doi: 10.1038/nature21392
p.411
Compared to using conventional jet fuel, the use of a biofuel blend reduces aircraft engine particle emissions at cruising altitude by about 50–70 per cent.doi: 10.1038/nature21420
p.416
A model of the conditions required for episodic tremor and accompanying slow slip to occur, near the megathrust seismogenic zone, reconciles seemingly contradictory observations.doi: 10.1038/nature21389
p.420
Steranes in ancient rocks have been used as ‘molecular fossils’, but the very earliest records of steranes have been shown to be contaminants; here, the presence of two key sterol biosynthesis enzymes in eukaryotes and bacteria suggests at least one gene transfer between bacteria and the earliest eukaryotes occurred some 2.3 billion years ago.doi: 10.1038/nature21412
p.424
The glycolytic activity of Paneth cells provides lactate, which is required by self-renewing intestinal stem cells for oxidative metabolism to activate p38 MAP kinase, ensuring regeneration of a mature crypt.doi: 10.1038/nature21673
p.428
A selective class IIa histone deacetylase inhibitor induces anti-tumour immunity in a mouse model of mammary cancer through altered differentiation and recruitment of tumour-associated macrophages.doi: 10.1038/nature21409
p.433
SZT2 recruits GATOR1 and GATOR2 to form a SZT2-orchestrated GATOR (SOG) complex at the lysosome that is essential for GATOR- and SESN-dependent nutrient sensing and mTORC1 regulation.doi: 10.1038/nature21378
p.438
A protein complex composed of KPTN, ITFG2, C12orf66 and SZT2, named KICSTOR, is necessary for lysosomal localization of GATOR1, interaction of GATOR1 with the Rag GTPases and GATOR2, and nutrient-dependent mTORC1 modulation.doi: 10.1038/nature21423
p.443
Proteins prone to aggregation in yeast are imported into mitochondria under stress conditions, suggesting that mitochondrial import and proteolysis may help to disaggregate proteins in the cytoplasm.doi: 10.1038/nature21695
p.447
The intrinsically disordered CITED2 negative feedback regulator displaces the tightly bound hypoxia-inducible transcription factor HIF-1α from their common target TAZ1 through the formation of an intermediate ternary complex and thereby attenuates the hypoxic response.doi: 10.1038/nature21705
