Dutch elections signal next test for rise in populism p.149
Science is already losing out in the Netherlands.doi: 10.1038/543149b
Volume 543 Issue 7644
리서치 하이라이트
표지 기사： 타임 크리스탈에 대한 관찰 결과
고대 유목민들의 고산 지대 이동 경로를 따라 형성된 실크로드
정확한 5′ 말단을 가진 인간 lncRNA에 대한 아틀라스
젊거나 노화된 줄기 세포의 대사 및 기능 유지에 관여하는 자가 식작용
히스톤 메틸-라이신 결합 기능 매스킹에 의한 TIRR의 53BP1 조절 메커니즘
디자인된 촉매를 이용한 조절된 키랄성 성장을 가지는 수평 탄소 나노튜브 어레이
지구 최초의 안정적인 고대 지각
월바치아에 의해 유도된 세포질 불안정성에 대한 프로파아지 WO 유전자
단일 저용량 유전자 변형 mRNA를 이용한 지카 바이러스 예방 백신
컨텐츠
Editorials
Rising to the challenge as US states turn the screw on science education p.149
Researchers everywhere should pay more attention to how their subject is presented.doi: 10.1038/543149a
Science journalism can be evidence-based, compelling — and wrong p.150
A ranking of the best science-news outlets misjudges the relationship between research and reporting.doi: 10.1038/543150a
News
How the fallout from Trump's travel ban is reshaping science p.157
Researchers are cutting short travel, ending collaborations and rethinking their US ties.doi: 10.1038/nature.2017.21579
IBM's quantum cloud computer goes commercial p.159
Company plans a bigger, better system aimed at creating a market for the still-immature technology.doi: 10.1038/nature.2017.21585
How rival bots battled their way to poker supremacy p.160
Artificial-intelligence programs harness game-theory strategies and deep learning to defeat human professionals in two-player hold 'em.doi: 10.1038/nature.2017.21580
Peer-review activists push psychology journals towards open data p.161
Editor asked to resign from journal for saying he’ll review only papers whose data he can see.doi: 10.1038/nature.2017.21549
Quantum microscope offers MRI for molecules p.162
Diamond-based imaging system uses magnetic resonance of electrons to detect charged atoms and peer at chemical reactions in real time.doi: 10.1038/nature.2017.21573
Neanderthal tooth plaque hints at meals — and kisses p.163
Analysis paints picture of diets, medicine and possible intimacy with humans.doi: 10.1038/543163a
News Features
The quest to crystallize time p.164
Bizarre forms of matter called time crystals were supposed to be physically impossible. Now they’re not.doi: 10.1038/543164a
How Facebook, fake news and friends are warping your memory p.168
Research on collective recall takes on new importance in a post-fact world.doi: 10.1038/543168a
News & Views
Manipulation of the manipulators p.182
Wolbachia bacteria infect insects and can cause mating incompatibilities, an outcome that is used to fight insect-transmitted disease. The proposed genes responsible illuminate this process and the disease-control mechanisms. See Letter p.243doi: 10.1038/nature21509
More uses for genomic junk p.183
It emerges that nascent non-coding RNAs transcribed from regulatory DNA sequences called enhancers bind to the enzyme CBP to promote its activity locally. In turn, the activities of CBP stimulate further enhancer transcription.doi: 10.1038/543183a
Marching to a different quantum beat p.185
Periodic oscillations are common in nature but they generally decay or fall out of phase. Two experiments have found evidence for a Floquet time crystal, which is characterized by persistent in-phase oscillations. See Letters p.217 & p. 221doi: 10.1038/543185a
Reading the future of leukaemia p.186
The identification of the regulatory protein ENL as essential to an aggressive form of leukaemia provides insight into transcriptional regulation and highlights potential avenues for therapy. See Letters p.265 & p.270doi: 10.1038/nature21894
Digital maps illuminate ancient trade routes p.188
How did the relationship between human societies and their surrounding terrain shape the formation of long-distance trade networks such as the Silk Road? Digital mapping and computer modelling offer insights. See Article p.193doi: 10.1038/543188a
Single-atom data storage p.189
The ultimate limit of classical data storage is a single-atom magnetic bit. Researchers have now achieved the writing and reading of individual atoms whose magnetic information can be retained for several hours. See Letter p.226doi: 10.1038/543189a
The chronicles of T-cell exhaustion p.190
T cells of the immune system often fail to target cancer cells because they enter a dysfunctional state known as exhaustion. Molecular analysis of T-cell exhaustion provides insights into the clinical use of these cells.doi: 10.1038/nature21508
Articles
Nomadic ecology shaped the highland geography of Asia’s Silk Roads p.193
The authors use modelling to show that the network of trading routes known as the Silk Road emerged from hundreds of years of interactions between pastoralists as they moved their herds and flocks between higher and lower elevations in generally mountainous regions.doi: 10.1038/nature21696
An atlas of human long non-coding RNAs with accurate 5′ ends p.199
A catalogue of human long non-coding RNA genes and their expression profiles across samples from major human primary cell types, tissues and cell lines.doi: 10.1038/nature21374
Autophagy maintains the metabolism and function of young and old stem cells p.205
Loss of autophagy increases the accumulation of mitochondria and the respiration status of haematopoietic stem cells, which perturbs their self-renewal and regeneration activities, and promotes cellular aging.doi: 10.1038/nature21388
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function p.211
A new protein, Tudor interacting repair regulator (TIRR), affects DNA repair by masking the chromatin interaction domain of 53BP1, thereby preventing its recruitment to double-strand breaks.doi: 10.1038/nature21358
Letters
Observation of a discrete time crystal p.217
A time crystal is a state of matter that shows robust oscillations in time, and although forbidden in equilibrium, a discrete time crystal has now been observed in a periodically driven quantum system.doi: 10.1038/nature21413
Observation of discrete time-crystalline order in a disordered dipolar many-body system p.221
Discrete time-crystalline order is observed in a driven, disordered ensemble of about one million dipolar spin impurities in diamond at room temperature, and is shown to be very stable to perturbations.doi: 10.1038/nature21426
Reading and writing single-atom magnets p.226
A two-bit magnetic memory is demonstrated, based on the magnetic states of individual holmium atoms, which are read and written in a scanning tunnelling microscope set-up and are stable over many hours.doi: 10.1038/nature21371
Amplified stimulated emission in upconversion nanoparticles for super-resolution nanoscopy p.229
Super-resolution optical microscopy based on stimulated emission depletion effects can now be performed at much lower light intensities than before by using bright upconversion emission from thulium-doped nanoparticles.doi: 10.1038/nature21366
Arrays of horizontal carbon nanotubes of controlled chirality grown using designed catalysts p.234
Horizontal arrays of metallic or semiconducting carbon nanotubes with controlled chirality are grown from specially designed solid carbide catalysts.doi: 10.1038/nature21051
Earth’s first stable continents did not form by subduction p.239
Phase equilibria modelling of rocks from Western Australia confirms that the ancient continental crust could have formed by multistage melting of basaltic ‘parents’ along high geothermal gradients—a process incompatible with modern-style subduction.doi: 10.1038/nature21383
Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility p.243
The discovery of two genes encoded by prophage WO from Wolbachia that functionally recapitulate and enhance cytoplasmic incompatibility in arthropods is the first inroad in solving the genetic basis of reproductive parasitism.doi: 10.1038/nature21391
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination p.248
A single, low-dose intradermal immunization with lipid-nanoparticle-encapsulated nucleoside-modified mRNA encoding the pre-membrane and envelope glycoproteins of Zika virus protects both mice and rhesus macaques against infection and elicits rapid and long-lasting neutralizing antibody responses.doi: 10.1038/nature21428
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism p.252
FABP4 and FABP5 are important for the maintenance, longevity and function of CD8+ tissue-resident memory T cells, which use oxidative metabolism of exogenous free fatty acids to persist in tissues and to mediate protective immunity.doi: 10.1038/nature21379
Reconstitution of the tubular endoplasmic reticulum network with purified components p.257
In the presence of GTP, a tubular endoplasmic reticulum network can be reconstituted with only two purified membrane proteins.doi: 10.1038/nature21387
The molecular architecture of lamins in somatic cells p.261
Cryo-electron tomography reveals a detailed view of the structural organization of the lamin meshwork within the lamina of the mammalian cell nucleus.doi: 10.1038/nature21382
ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia p.265
The chromatin-reader protein ENL regulates oncogenic programs in acute myeloid leukaemia by binding via its YEATS domain to acetylated histones on the promoters of actively transcribed genes and recruiting the transcriptional machinery.doi: 10.1038/nature21687
Transcription control by the ENL YEATS domain in acute leukaemia p.270
ENL, identified in a genome-scale loss-of-function screen as a crucial requirement for proliferation of acute leukaemia, is required for leukaemic gene expression, and its YEATS chromatin-reader domain is essential for leukaemic growth.doi: 10.1038/nature21688
