Data on movements of refugees and migrants are flawed p.5
Accurate and timely information on the flow of people is crucial for policymaking and apolitical interpretations.doi: 10.1038/543005b
Volume 543 Issue 7643
리서치 하이라이트
표지 기사： 비자 정책과 이민 간의 상관관계
해양에서의 생물지질화학에서 철의 통합적 역할
초기 지구 해저 열수 분출공에서 생명체 생성 관련 증거
췌장 신경분비샘 암에 대한 전체 지놈 염기서열 분석
비정상적인 전사 개시를 방지하는 유전자 내부 DNA 메틸화
코엔자임 F430에 의한 메탄 생합성 과정 조절
블랙홀의 내부 강착 디스크에서 가스의 아웃 플로우
지구 핵에서 이산화규소의 결정화 과정
고셔병 발병에 대한 보체계 활성화와 글루코실세라마이드의 축적 및 염증 간의 상관 관계
CRISPR/Cas9에 의해 도입된 TRAC 유전자위를 통한 CAR 세포 치료제 개발
컨텐츠
Editorials
Regulatory reform puts US waters in jeopardy p.5
The Clean Water Rule is under threat — but it is grounded in science and should be strengthened, not repeal.doi: 10.1038/543005a
Sci-fi comic still has thrill power p.6
After 40 years, 2000 AD deserves to be known for more than Judge Dredd.doi: 10.1038/543006a
News
African countries mobilize to battle invasive caterpillar p.13
Authorities and researchers ramp up their efforts to tackle the invasive fall armyworm.doi: 10.1038/nature.2017.21527
A giant neuron found wrapped around entire mouse brain p.14
3D reconstructions show a 'crown of thorns' shape stemming from a region linked to consciousness.doi: 10.1038/nature.2017.21539
The drug-resistant bacteria that pose the greatest health threats p.15
World Health Organization publishes list that it hopes will focus development of antibiotics.doi: 10.1038/nature.2017.21550
Astronomers grapple with new era of fast radio bursts p.16
Signals have progressed from astronomical peculiarity to mainstream research area.doi: 10.1038/543016a
Hepatitis C drugs re-energize global fight over patents p.17
Lawsuits in India and Argentina seek to reduce drug costs by allowing generic versions of antiviral treatments.doi: 10.1038/543017a
How to kill wild animals humanely for conservation p.18
An international group offers guidance to help reduce pain and suffering in animals destined for culling.doi: 10.1038/nature.2017.21536
News Features
Human migration p.21
A special issue explores the intersection of science and migration.doi: 10.1038/543021a
What the numbers say about refugees p.22
The biggest concentrations of displaced people lie far from the spotlight.doi: 10.1038/543022a
Hunted, haunted, stateless and scared: the stories of refugee scientists p.24
Displaced researchers face huge challenges making lives abroad, even if they find work.doi: 10.1038/543024a
News & Views
Lessons from tooth enamel p.42
A remarkable composite material has been made that mimics the structure of tooth enamel. This achievement opens up the exploration of new composite materials and of computational methods that reliably predict their properties. See Letter p.95doi: 10.1038/543042a
Stretched divisions p.43
Many organ surfaces are covered by a protective epithelial-cell layer. It emerges that such layers are maintained by cell stretching that triggers cell division mediated by the force-sensitive ion-channel protein Piezo1. See Letter p.118doi: 10.1038/nature21502
Subduction undone p.44
Rocks are subjected to increased pressure as they are buried during subduction. Contrary to general belief, a study suggests that peak pressures recorded in subducted rocks might not reflect their maximum burial depths.doi: 10.1038/543044a
Commonality with cancer p.45
Ageing is associated with an increased risk of cardiovascular disease caused by the rupture of inflamed cholesterol plaques in arteries. It emerges that this might be partly due to genetic mutations that cause cancerous changes in white blood cells.doi: 10.1038/nature21505
A solid more fluid than a fluid p.47
A supersolid is a paradoxical and elusive state of matter that has been sought for more than 60 years. Two experiments have now observed its characteristic signatures in ultracold quantum matter. See Letters p.87 & p.91doi: 10.1038/543047a
T-cell tweaks to target tumours p.48
Immune cells known as T cells can destroy tumour cells, but their clinical use requires complex preparation and the cells can lose effectiveness over time. A new approach might improve the efficiency of T-cell therapy. See Letter p.113doi: 10.1038/nature21506
Origin of a key player in methane biosynthesis p.49
The biosynthesis of a coenzyme in the microbial production of methane has been determined — completing the biosynthetic pathways for the family of compounds that includes chlorophyll, haem and vitamin B12. See Article p.78doi: 10.1038/nature21507
Review
The integral role of iron in ocean biogeochemistry p.51
doi: 10.1038/nature21058
Articles
Evidence for early life in Earth’s oldest hydrothermal vent precipitates p.60
Perhaps the earliest known signs of life have been found in Quebec, where features such as haematite tubes suggest that filamentous microbes lived around hydrothermal vents at least 3,770 million years ago.doi: 10.1038/nature21377
Whole-genome landscape of pancreatic neuroendocrine tumours p.65
The genomes of 102 primary pancreatic neuroendocrine tumours have been sequenced, revealing mutations in genes with functions such as chromatin remodelling, DNA damage repair, mTOR activation and telomere maintenance, and a greater-than-expected contribution from germ line mutations.doi: 10.1038/nature21063
Intragenic DNA methylation prevents spurious transcription initiation p.72
Intragenic DNA methylation, dependent on Dnmt3b, protects the gene body from spurious entry of RNA Polymerase II and aberrant transcription initiation events.doi: 10.1038/nature21373
Elucidation of the biosynthesis of the methane catalyst coenzyme F430 p.78
The enzymes and pathway involved in the biosynthesis of coenzyme F430 are identified, completing our understanding of how members of the cyclic modified tetrapyrrole family are constructed.doi: 10.1038/nature21427
Letters
The response of relativistic outflowing gas to the inner accretion disk of a black hole p.83
X-ray detection of an ultrafast outflow of gas is strongly linked with energy emission from the inner accretion disk of a black hole, suggesting that X-rays ionize the outflowing disk wind.doi: 10.1038/nature21385
Supersolid formation in a quantum gas breaking a continuous translational symmetry p.87
A supersolid with continuous translational symmetry breaking along one direction is realized by symmetrically coupling a Bose–Einstein condensate to the modes of two optical cavities.doi: 10.1038/nature21067
A stripe phase with supersolid properties in spin–orbit-coupled Bose–Einstein condensates p.91
Spin–orbit coupling in Bose–Einstein condensates creates a density modulation, which is a stripe phase with supersolid properties.doi: 10.1038/nature21431
Abiotic tooth enamel p.95
Nanometre-scale columnar structures in tooth enamel inspire novel nanocomposites containing layers of vertically aligned nanowires, produced by layer-by-layer fabrication and combining high values of both storage modulus and energy dissipation.doi: 10.1038/nature21410
Crystallization of silicon dioxide and compositional evolution of the Earth’s core p.99
Melting experiments with liquid Fe–Si–O alloy at the pressure of the Earth’s core reveal that the crystallization of silicon dioxide leads to core convection and a dynamo.doi: 10.1038/nature21367
Prefrontal cortex output circuits guide reward seeking through divergent cue encoding p.103
Neurons that project from the prefrontal cortex to either the nucleus accumbens or paraventricular thalamus receive different inputs, differentially encode reward-predictive cues, and have opposing effects on reward seeking during cue presentation.doi: 10.1038/nature21376
Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease p.108
Complement-activating glycosylceramide-specific autoantibodies drive a self-propagating cycle of glycosylceramide accumulation and inflammation in Gaucher disease.doi: 10.1038/nature21368
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection p.113
Introducing chimeric antigen receptors into the endogenous T-cell receptor locus reduces tonic signalling, averts accelerated T-cell differentiation and delays T-cell exhaustion, leading to enhanced function and anti-tumour efficacy compared to random integrations.doi: 10.1038/nature21405
Mechanical stretch triggers rapid epithelial cell division through Piezo1 p.118
The stretch-activated channel Piezo1 controls homeostatic epithelial cell numbers by activating cells to divide rapidly when under stretch strain from low density, and by activating cells to extrude and die when cells are under crowding strain.doi: 10.1038/nature21407
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity p.122
Circular extrachromosomal DNA is found in nearly half of human cancers of a wide variety of histologic types, increasing the copy number of driver oncogenes and intratumoral heterogeneity more effectively than chromosomal amplification and contributing to tumor evolution.doi: 10.1038/nature21356
Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy p.126
Uniparental disomy in fission yeast is triggered by aberrant expression of gametogenic genes in vegetative cells, and is associated with the activation of meiotic cohesin Rec8 in cells with defects in the RNA interference machinery.doi: 10.1038/nature21372
Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL p.131
A new approach, time-resolved serial femtosecond crystallography, is used to view the intermediate states of a photosystem complex following illumination, shedding light on proton transfer and O=O bond formation.doi: 10.1038/nature21400
