Replication studies offer much more than technical details p.259
They demonstrate the practice of science at its best.doi: 10.1038/541259b
Volume 541 Issue 7637
Editorials
Trump’s vaccine-commission idea is biased and dangerous p.259
Scientists must fight back with the truth about the debunked link between vaccines and autism.doi: 10.1038/541259a
Base the social cost of carbon on the science p.260
The potential economic damage from global warming should not be influenced by politics.doi: 10.1038/541260a
News
India’s first GM food crop held up by lawsuit p.267
Scientists accused of deceiving the public about benefits of transgenic mustard.doi: 10.1038/541267a
Cancer reproducibility project releases first results p.269
An open-science effort to replicate dozens of cancer-biology studies is off to a confusing start.doi: 10.1038/541269a
Gates Foundation research can’t be published in top journals p.270
Publications such as Nature and Science have policies that clash with the global health charity's open-access mandate.doi: 10.1038/nature.2017.21299
Space-weather forecast to improve with European satellite p.271
Probe could give early warnings of catastrophic solar storms heading for Earth.doi: 10.1038/541271a
Croatia’s science minister rejects calls to resign amid plagiarism scandal p.272
Pavo Barišić says he won't step down after a parliamentary ethics committee found he copied another scholar's work.doi: 10.1038/541272a
US energy agency strengthens protections for scientists p.272
Revised scientific-integrity policy gives researchers more leeway to speak to the press and publish their findings.doi: 10.1038/nature.2017.21290
News Features
The $2.4-billion plan to steal a rock from Mars p.274
NASA is now building the rover that it hopes will bring back signs of life on the red planet.doi: 10.1038/541274a
Five big mysteries about CRISPR’s origins p.280
Where did it come from? How do organisms use it without self-destructing? And what else can it do?doi: 10.1038/541280a
News & Views
Quiet moments in time p.292
'Squeezed' light exhibits smaller quantum fluctuations than no light at all. Localized squeezed regions have now been produced along an infrared light wave and probed with unprecedented time resolution. See Letter p.376doi: 10.1038/541292a
Messenger RNAs marked for longer life p.293
A molecular modification called m6Am has been found to regulate the stability of messenger RNAs in mammalian cells. The mechanism casts fresh light on how reversibly modified RNA bases control the fate of mRNA. See Article p.371doi: 10.1038/nature21109
Shoppers like what they know p.294
Faced with ever-changing products, consumers can benefit from trying new items. But data collected over almost five years show that, the longer shoppers have been buying a favourite product, the more likely they are to stick with it.doi: 10.1038/nature21114
Algorithm for architectural origami p.296
An algorithm has been developed allowing the rational design of origami-inspired materials that can be rearranged to change their properties. This might open the way to strategies for making reconfigurable robots. See Article p.347doi: 10.1038/541296a
Mind the gaps in cellular evolution p.297
Eukaryotic cells, with complex features such as membrane-bound nuclei, evolved from prokaryotic cells that lack these components. A newly identified prokaryotic group reveals intermediate steps in eukaryotic-cell evolution. See Article p.353doi: 10.1038/nature21113
Ins and outs of picornaviruses p.299
Competition between the phospholipase enzyme PLA2G16 and the protein galectin-8 determines whether the RNA-based genomes of picornaviruses can be effectively delivered into host cells. See Letter p.412doi: 10.1038/nature21116
Articles
Rational design of reconfigurable prismatic architected materials p.347
doi: 10.1038/nature20824
Asgard archaea illuminate the origin of eukaryotic cellular complexity p.353
doi: 10.1038/nature21031
Genomic hallmarks of localized, non-indolent prostate cancer p.359
doi: 10.1038/nature20788
Integration of temporal and spatial patterning generates neural diversity p.365
doi: 10.1038/nature20794
Reversible methylation of m6Am in the 5′ cap controls mRNA stability p.371
doi: 10.1038/JNature7637af-5
Reversible methylation of m6 Am in the 5′ cap controls mRNA stability
p.371
Fat mass and obesity-associated protein (FTO) preferentially demethylates m6Am, a modified adenosine that, when present at the 5′ end of certain mRNAs, positively influences mRNA stability by preventing DCP2-mediated decapping.
doi: 10.1038/nature21022
Letters
Subcycle quantum electrodynamics p.376
doi: 10.1038/nature21024
Kinetically E-selective macrocyclic ring-closing metathesis p.380
doi: 10.1038/nature20800
Evolution of the global phosphorus cycle p.386
doi: 10.1038/nature20772
Hurricane intensification along United States coast suppressed during active hurricane periods p.390
doi: 10.1038/nature20783
Hyoliths are Palaeozoic lophophorates p.394
doi: 10.1038/nature20804
A theoretical foundation for multi-scale regular vegetation patterns p.398
doi: 10.1038/nature20801
Genetic variants regulating expression levels and isoform diversity during embryogenesis p.402
doi: 10.1038/nature20802
Structural basis for nutrient acquisition by dominant members of the human gut microbiota p.407
doi: 10.1038/nature20828
PLA2G16 represents a switch between entry and clearance of Picornaviridae p.412
doi: 10.1038/nature21032
Microenvironmental autophagy promotes tumour growth p.417
doi: 10.1038/nature20815
The role of interfacial lipids in stabilizing membrane protein oligomers p.421
doi: 10.1038/nature20820
