The historic truth about science fiction from H. G. Wells to Star Trek p.137
Science fiction fights the past as much as it faces the future.doi: 10.1038/537137b
Volume 537 Issue 7619
리서치 하이라이트
표지 기사： 사이언스 픽션의 현재와 미래
빛을 통해서 조절되는 액정 폴리머 마이크로액추에이터
구조 기반 분석을 통해 부작용을 줄인 오피오이드 수용체 작용제를 이용한 통증 치료제 개발
인트론 제거에 관여하는 스플라이소솜의 냉동 전자 현미경 구조 분석
분자 샤페론의 작용 메커니즘에 대한 구조 기반 분석
오리온 성운에 존재하는 오리온 바의 압축된 형태 분석
저분자 철 촉매에 의한 아미노산 및 팹타이트 산화성 다양화
물고기 지느러미에서 진화한 사족류 사지 및 손발가락 발달에 관여하는 Hox 유전자
샤가스병, 리슈마니아증, 그리고 수면병을 동시에 치료할 수 있는 새로운 동원핵편모충류 프로테아솜 타깃 약물
X 염색체 유전자 발현에 관여하는 PionX
컨텐츠
Editorials
Macchiarini scandal is a valuable lesson for the Karolinska Institute p.137
Procedures have rightly been tightened in response to the controversy surrounding surgeon Paolo Macchiarini — but the institute must take care not to restrict its science.doi: 10.1038/537137a
Announcement: Where are the data? p.138
doi: 10.1038/537138a
News
Mars contamination fear could divert Curiosity rover p.145
NASA must avoid spreading Earth microbes to suspected water in hillside streaks.doi: 10.1038/537145a
London super-lab opens under cloud of Brexit p.147
Research begins at the unabashedly international Francis Crick Institute.doi: 10.1038/nature.2016.20530
Boom in unproven cell therapies intensifies regulatory debate p.148
Controversial US guidelines attempt to rein in rogue stem-cell clinics.doi: 10.1038/537148a
Venerable brain-cancer cell line faces identity crisis p.149
Samples of the cell line do not match its 50-year-old source ― but how the mix-up occurred is a mystery.doi: 10.1038/nature.2016.20515
US science agencies face budget limbo p.149
Likelihood of stopgap spending measure grows.doi: 10.1038/537149a
News Features
How to raise a genius: lessons from a 45-year study of super-smart children p.152
A long-running investigation of exceptional children reveals what it takes to produce the scientists who will lead the twenty-first century.doi: 10.1038/537152a
The new breed of cutting-edge catalysts p.156
Advances in catalyst research could create a superhighway to clean energy sources and a more-sustainable chemical industry.doi: 10.1038/537156a
News & Views
Designing the ideal opioid p.170
The development of a drug that mimics the pain-relieving activity of opioid compounds, but has fewer side effects, points to an effective strategy for the discovery of many types of drug. See Article p.185doi: 10.1038/nature19424
Slippery when narrow p.171
An experimental technique has been developed to measure water flow through carbon nanotubes. Measurements reveal that flow can be almost frictionless, posing challenges for computer simulations of nanofluidics. See Letter p.210doi: 10.1038/537171a
Mapping the terrestrial human footprint p.172
An analysis of direct human impacts across Earth's land surface using global satellite images and ground surveys reveals the scale of the 'human footprint' on the world and its changes between 1993 and 2009.doi: 10.1038/537172a
Violent emissions of newborn stars p.174
Interactions between young stars and their parent molecular clouds are poorly understood. High-resolution observations of the Orion nebula now reveal these interactions, which have implications for star formation. See Letter p.207doi: 10.1038/537174a
Catalytic spliceosome captured p.175
Spliceosome complexes remove non-coding sequences from RNA transcripts in two steps. A structure of a spliceosome after the first step reveals active-site interactions and evolutionary constraints on these non-coding regions. See Article p.197doi: 10.1038/nature19422
Fin to limb within our grasp p.176
There was thought to be little in common between fish fin bones and the finger bones of land-dwellers. But zebrafish studies reveal that hox genes have a surprisingly similar role in patterning the two structures. See Letter p.225doi: 10.1038/nature19425
Articles
Photocontrol of fluid slugs in liquid crystal polymer microactuators p.179
A light-actuated liquid crystal polymer material system precisely manipulates liquid drops through capillary forces, and can be formed into a variety of shapes.doi: 10.1038/nature19344
Structure-based discovery of opioid analgesics with reduced side effects p.185
Computational docking to the the μ-opioid-receptor identifies PZM21, a novel selective biased agonist that generates substantial affective analgesia in mice without altering respiration or inducing drug reinforcement.doi: 10.1038/nature19112
Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution p.191
The cryo-electron microscopy structure of the rabbit voltage-gated calcium channel Cav1.1 complex at a nominal resolution of 3.6 ångströms.doi: 10.1038/nature19321
Cryo-EM structure of the spliceosome immediately after branching p.197
Cryo-EM reveals the configuration of substrate pre-mRNA within the active spliceosome and suggests how remodelling occurs prior to exon ligation.doi: 10.1038/nature19316
Structural basis for the antifolding activity of a molecular chaperone p.202
The solution structure of SecB, a molecular chaperone that exhibits strong antifolding activity, in complex with alkaline phosphatase and maltose-binding protein captured in their unfolded states.doi: 10.1038/nature18965
Letters
Compression and ablation of the photo-irradiated molecular cloud the Orion Bar p.207
One-arcsecond-resolution millimetre-wave images enable the surface of the Orion Bar molecular cloud to be resolved, revealing a fragmented ridge of high-density substructures, photoablative gas flows and instabilities that suggest that the cloud edge has been compressed by a high-pressure wave expanding into the molecular cloud, in contrast to predictions from static equilibrium models.doi: 10.1038/nature18957
Massive radius-dependent flow slippage in carbon nanotubes p.210
The pressure-driven flow rate through individual carbon nanotubes is precisely determined from the hydrodynamics of emerging water jets, revealing unexpectedly large and radius-dependent surface slippage.doi: 10.1038/nature19315
Oxidative diversification of amino acids and peptides by small-molecule iron catalysis p.214
Two small-molecule iron catalysts are shown to be capable of facilitating the targeted C–H oxidative modification of amino acids and peptides with preservation of α-centre chirality (a challenging synthesis), producing a diverse range of amino acids and peptides.doi: 10.1038/nature18941
A progressively wetter climate in southern East Africa over the past 1.3 million years p.220
A 1.3-million-year-long climate history from the Lake Malawi basin in eastern Africa displays a trend towards progressively wetter conditions superimposed on strong 100,000-year eccentricity cycles of temperature and rainfall since the Mid-Pleistocene Transition around 900,000 years ago.doi: 10.1038/nature19065
Digits and fin rays share common developmental histories p.225
Hoxa- and Hoxd-deficient zebrafish generated using Crispr/Cas with fate mapping have reduced fin rays and increased endochondral elements, establishing homology between the developmental programs that create fin rays and the wrists and digits of mammals.doi: 10.1038/nature19322
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness p.229
A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious in vivo, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.doi: 10.1038/nature19339
Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system p.234
Hypoxia in germinal centres regulates B cell class switching via its effects on mTOR complex 1 and activation-induced cytosine deaminase activity.doi: 10.1038/nature19334
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan p.239
The long non-coding RNA Morrbid controls myeloid cell lifespan and regulates apoptosis by repressing the adjacent pro-apoptotic Bcl2l11 gene in cis.doi: 10.1038/nature19346
PionX sites mark the X chromosome for dosage compensation p.244
Recognition of the X chromosome by the dosage compensation complex in Drosophila relies on the sequence and shape of PionX sites.doi: 10.1038/nature19338
Insights from biochemical reconstitution into the architecture of human kinetochores p.249
Biochemical reconstitution of a synthetic human kinetochore with 21 protein subunits and centromeric nucleosomal DNA unveils fundamental principles of kinetochore organization and function.doi: 10.1038/nature19333
