Non-expert nation p.589
Scientists — just like everybody else — have little idea what will happen now that the United Kingdom has voted to exit the European Union.doi: 10.1038/534589a
Volume 534 Issue 7609
리서치 하이라이트
표지 기사： 액체의 고체 표면 부착과 정지 마찰 간의 전환
64만년 전 아시아 몬순 기후에 대한 기록과 빙하기의 종식
KRAS 돌연변이 폐암 세포 치료를 위한 조합 치료
포유류 초기 이식 배아에서의 염색질 구성 및 조절 인자
5백만년~1천만년 정도된 젊은 별 주변을 공전하고 있는 해왕성 크기의 행성
튜닝 가능한 단일 레이드버그 원자의 2차원 어레이를 통한 이싱 모델 현실화
세균의 돌연변이 생성에 대한 확률 및 메커니즘
숙주에 의한 당류 산화를 통한 항생제 치료 후 병원성 세균 증식 메커니즘
심실 벽 구성과 관련된 심근 세포 상호작용
쌍 패각류에서 확인된 전이성 암 조직
컨텐츠
Editorials
The big picture p.589
Problems of modern society demand collaborative research.doi: 10.1038/534589b
Calculated risks p.590
The perils of the past must not be allowed to happen againdoi: 10.1038/534590a
News
UK scientists in limbo after Brexit shock p.597
Researchers organize to lobby for science as country prepares for life outside the EU.doi: 10.1038/534597a
NASA’s Juno spacecraft prepares to probe Jupiter’s mysteries p.599
The mission will peek through the gas giant’s swirling clouds in search of a planetary core.doi: 10.1038/534599a
Stressed Indus River threatens Pakistan’s water supplies p.600
Cooler, cloudier summers slow snowmelt in Himalayasdoi: 10.1038/534600a
ArXiv preprint server plans multimillion-dollar overhaul p.602
Users urge caution in revamp of service at the heart of physics.doi: 10.1038/534602a
News Features
The inside story on the world’s most famous sheep p.604
From incubation in a bra to an afterlife under glass, how a cloned sheep attained celebrity status.doi: 10.1038/534604a
Why ultra-powerful radio bursts are the most perplexing mystery in astronomy p.610
Strange signals are bombarding Earth. But where are they coming from?doi: 10.1038/534610a
News & Views
The dark side of antibiotics p.624
Interactions in the gut between host cells and bacteria can determine a state of health or disease. A study investigates how antibiotic treatment can affect host cells in a way that drives growth of pathogenic bacteria. See Letter p.697doi: 10.1038/nature18449
Stressed-out chromatin promotes longevity p.625
Two studies reveal that early-life malfunction in organelles called mitochondria brings about lasting changes in how DNA is packaged. These alterations have consequences for cellular stress responses and organismal longevity.doi: 10.1038/534625a
An extended yardstick for climate variability p.626
Decoded and precisely dated information encrypted in stalagmites from a cave in China reveal past climatic changes and provide insight into the complex interactions in today's climate system. See Letter p.640doi: 10.1038/534626a
Transmissible tumours under the sea p.628
In some species, cancer cells can be directly transmitted between individuals. An analysis in shellfish now shows that some transmissible cancers can even cross the species barrier. See Letter p.705doi: 10.1038/nature18455
Perspective
Paris Agreement climate proposals need a boost to keep warming well below 2 °C p.631
The objective of the Paris climate agreement is to limit global-average temperature increase to well below 2 degrees Celsius above pre-industrial levels and to further pursue limiting it to 1.5 degrees Celsius; here, the adequacy of the national plans submitted in preparation for this agreement is assessed, and it is concluded that substantial enhancement or over-delivery on these plans is required to have a reasonable chance of achieving the Paris climate objective.doi: 10.1038/nature18307
Articles
The Asian monsoon over the past 640,000 years and ice age terminations p.640
Records of the Asian monsoon have been extended to 640,000 years ago, and confirm both that the 100,000-year ice age cycle results from integral numbers of precessional cycles and that insolation influences the pacing of major millennial-scale climate events.doi: 10.1038/nature18591
A combinatorial strategy for treating KRAS-mutant lung cancer p.647
A systematic screen identifies FGFR1 signalling reactivation as an adaptive resistance mechanism after MEK inhibition specific for KRAS tumours, which can be targeted by combined inhibition with the clinically approved drugs trametinib and ponatinib.doi: 10.1038/nature18600
The landscape of accessible chromatin in mammalian preimplantation embryos p.652
An improved ATAC-seq approach is used to describe a genome-wide view of accessible chromatin and cis-regulatory elements in mouse preimplantation embryos, allowing construction of a regulatory network of early development that helps to identify key modulators of lineage specification.doi: 10.1038/nature18606
Letters
A Neptune-sized transiting planet closely orbiting a 5–10-million-year-old star p.658
A fully formed, Neptune-sized planet is observed orbiting a young star, demonstrating that planets can form in less than 10 million years and may also experience inward migration on these timescales.doi: 10.1038/nature18293
A hot Jupiter orbiting a 2-million-year-old solar-mass T Tauri star p.662
The radial velocities of a young star are measured, revealing the presence of a planet of mass about three-quarters that of Jupiter, orbiting its host star very closely, and thus demonstrating that ‘hot Jupiters’ can migrate inwards in less than two million years.doi: 10.1038/nature18305
Tunable two-dimensional arrays of single Rydberg atoms for realizing quantum Ising models p.667
Many proof-of-principle platforms for quantum simulation of spin models have been implemented, but it is difficult to produce a design with sufficient flexibility to realize arbitrary geometries and variable distance; here a platform based on arrays of optical microtraps achieves this flexibility with large atom numbers.doi: 10.1038/nature18274
Synthetic Landau levels for photons p.671
It is an long-standing goal to produce a photonic quantum Hall effect, analogous to the well-known quantum Hall effect for electrons; now an artificial magnetic field for a continuum of photons has been produced, making it possible to observe photonic Landau levels in a photonic quantum Hall material.doi: 10.1038/nature17943
Switching stiction and adhesion of a liquid on a solid p.676
Switching of static friction and adhesion of a liquid drop on a corrugated solid boron nitride surface is linked to the intercalation of hydrogen, which changes the electric field of in-plane dipole rings and thus reduces the adsorption energy.doi: 10.1038/nature18275
Seasonality of temperate forest photosynthesis and daytime respiration p.680
Climate models require an understanding of ecosystem-scale respiration and photosynthesis, yet there is no way of measuring these two fluxes directly; here, new instrumentation is used to determine these fluxes in a temperate forest, showing, for instance, that respiration is less during the day than at night.doi: 10.1038/nature17966
Interdisciplinary research has consistently lower funding success p.684
The degree of interdisciplinarity in research proposals negatively correlates with funding success across a wide range of research fields.doi: 10.1038/nature18315
Basal forebrain projections to the lateral habenula modulate aggression reward p.688
Here, the circuits underlying the motivational or rewarding component to aggression are deconstructed, showing that an inhibitory projection from the basal forebrain to the lateral habenula bi-directionally controls this aspect of aggression.doi: 10.1038/nature18601
Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing p.693
Maximum-depth sequencing (MDS), a new method of detecting extremely rare variants within a bacterial population, is used to show that mutation rates in Escherichia coli vary across the genome by at least an order of magnitude, and also to uncover mechanisms of antibiotic-induced mutagenesis.doi: 10.1038/nature18313
Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion p.697
Antibiotic usage in humans can increase the risk of Salmonella infection by an unknown mechanism; this paper reveals that the antibiotic streptomycin increases the activity of the host-encoded enzyme inducible nitric oxide synthase, this then drives Salmonella expansion by the generation of galactarate — a metabolite normally absent from the gut.doi: 10.1038/nature18597
Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis p.700
A complex interplay involving Notch- and Erbb2-mediated signalling between cardiomyocytes guides the morphogenesis of the ventricular wall.doi: 10.1038/nature18310
Widespread transmission of independent cancer lineages within multiple bivalve species p.705
Disseminated neoplasias in three species of bivalve mollusc are attributed to transmissible clonal lines, and neoplasias in one species are caused by cross-species transmission of cancer, suggesting that transmissible neoplasia is common in marine species.doi: 10.1038/nature18599
Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation p.710
Acute protein folding stress in the mitochondrial matrix activates both increased chaperone availability within the matrix and reduced matrix-localized protein synthesis through translational inhibition.doi: 10.1038/nature18302
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex p.714
We have a limited understanding of how cells mark and identify newly replicated genomic loci that have a sister chromatid; here, unmethylated K20 in the tail of new histone H4 is shown to serve as a signature of post-replicative chromatin, which is specifically recognized by the homologous recombination complex TONSL–MMS22L.doi: 10.1038/nature18312
Translation readthrough mitigation p.719
Translation termination sequences are occasionally bypassed by the ribosome and the resulting proteins can be detrimental to the cell; here it is shown that cells can prevent such proteins from accumulating through peptides that are encoded within the 3' UTR of genes in both humans and C. elegans.doi: 10.1038/nature18308
Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution p.724
The first high-resolution structure of a human actomyosin complex reveals the interface between F-actin and myosin in near-atomic detail.doi: 10.1038/nature18295
