Down to earth p.411
A concerted focus on soils will benefit society in untold ways and should be embraced.doi: 10.1038/517411b
Volume 517 Issue 7535
리서치 하이라이트
표지 기사： 에스큐엘 석철 운석이 형성되는데 대한 메커니즘 규명
산화적 탄소-탄소 결합 추가에 의한 안정적인 금(III) 촉매 반응
내성 없이 병원균을 사멸시킬 수 있는 새로운 형태의 항생제
클라스린과 별개로 앤도시토시스 경로를 조절하는 기능이 있는 앤도필린
감수분열 특이적인 동원체 기능을 조절하는 MEIKIN 단백질
20세기 해수면 상승 예측을 위한 새로운 조수 간만 데이터
유전적 및 화학적 Kras발암 모델에서의 돌연변이 분포
mTORC1에 의한 번역 연장 제한에 의한 소화기 암의 개시 및 성장 억제 효과
한랭글로블린혈증에 대한 생쥐 모델에서 신장 질환을 억제하는 IgG1
컨텐츠
Editorials
Kept on a leash p.411
A vital dependence on genetically modified organisms on an artificial nutrient could be a means of preventing their escape into the environment.doi: 10.1038/517411a
Lost and found p.412
The discovery of Beagle 2 on Mars should spur the search for other items lost to science.doi: 10.1038/517412a
News
Attempts to predict terrorist attacks hit limits p.419
Erratic human behaviour and incomplete information plague efforts to model risk.doi: 10.1038/517419a
Psychologists seek roots of terror p.420
Studies raise prospect of intervention in the radicalization process.doi: 10.1038/517420a
Crunch time for pet theory on dark matter p.422
Thought to make up the Universe’s missing matter, WIMPs are running out of places to hide.doi: 10.1038/517422a
GM microbes created that can’t escape the lab p.423
Engineered bacteria kept in check with a designer diet.doi: 10.1038/517423a
CalWater 2015 targets atmospheric rivers off California p.424
Meteorologists investigate airborne jets that bring both floods and drought relief.doi: 10.1038/517424a
News Features
Blood to blood p.426
By splicing animals together, scientists have shown that young blood rejuvenates old tissues. Now, they are testing whether it works for humans.doi: 10.1038/517426a
Laser focus p.430
By firing lasers into the sky, Claire Max has transformed the capabilities of current — and future — telescopes.doi: 10.1038/517430a
News & Views
Gold unleashes the power of three p.440
Gold in the +3 oxidation state is scarcely used in catalysis, because the oxidants employed to generate it can damage reactants. An oxidant-free route to gold(III) catalysts reveals their potential. See Article p.449doi: 10.1038/517440a
Hold on and let go p.441
The discovery and functional analysis of the protein MEIKIN in mice leads to an evolutionarily conserved model of how chromosome segregation is regulated during a specialized type of cell division called meiosis I. See Article p.466doi: 10.1038/nature14087
An irresistible newcomer p.442
A screen of 10,000 bacterial strains, cultured in their normal soil, has uncovered an antibiotic with broad and potent activity. And because the compound targets lipid molecules, developing resistance is probably difficult. See Article p.455doi: 10.1038/nature14193
Cosmic fog and smog p.444
It emerges that most of the elements heavier than helium are not found in galaxies, where they can be mixed into future stars and planets. Instead, these elements largely reside far from galaxies in ionized gas and dust particles.doi: 10.1038/517444a
Monsoon matters p.445
A simplified global climate model that keeps track of water as it moves through Earth's water cycle throws fresh light on how the Asian summer monsoon has varied during the past 150,000 years.doi: 10.1038/517445a
On the endocytosis rollercoaster p.446
Endocytosis is a process by which molecules gain access to a cell. An unusual mode of endocytosis has now been shown to regulate cell signalling, and to be highjacked by bacterial toxins. See Article p.460 & Letter p.493doi: 10.1038/nature14081
Articles
Stable gold(III) catalysts by oxidative addition of a carbon–carbon bond p.449
The facile synthesis of a stable Au(III) cationic complex is described; this gold catalyst exhibits hard, oxophilic Lewis acidity, enabling selective conjugate additions and a [2 + 2] cycloaddition reaction.doi: 10.1038/nature14104
A new antibiotic kills pathogens without detectable resistance p.455
From a new species of β-proteobacteria, an antibiotic called teixobactin that does not generate resistance has been characterized; the antibiotic has two different lipid targets in different bacterial cell wall synthesis components, which may explain why resistance was not observed.doi: 10.1038/nature14098
Endophilin marks and controls a clathrin-independent endocytic pathway p.460
This study describes a fast, clathrin-independent endocytic pathway mediated by endophilin, dynamin and actin; the pathway is activated by ligand binding to a variety of cargo receptors, and endophilin-mediated endocytosis occurs primarily at the leading edges of cells where lamellipodin and the lipid PtdIns(3,4)P2 ensure endophilin targeting.doi: 10.1038/nature14067
Meikin is a conserved regulator of meiosis-I-specific kinetochore function p.466
The long elusive mammalian meiosis-specific kinetochore factor has been identified in mice; MEIKIN—which plays an equivalent role to the yeast proteins Spo13 and Moa1—ensures mono-orientation, protects sister chromatid cohesion and recruits the kinase PLK1 to the kinetochores.doi: 10.1038/nature14097
Letters
Long-lived magnetism from solidification-driven convection on the pallasite parent body p.472
Nanomagnetic imaging has been used to obtain a palaeomagnetic time series of two pallasite meteorites, revealing that their convection was driven by core solidification, which would have caused long-lived magnetic fields in the cores of early Solar System planetary bodies.doi: 10.1038/nature14114
Compositional engineering of perovskite materials for high-performance solar cells p.476
Inorganic–organic lead halide perovskite could be efficient when used as the light-harvesting component of solar cells; here incorporation of methylammonium lead bromide into formamidinium lead iodide stabilizes the perovskite and improves the power conversion efficiency of the solar cell up to 17.9 per cent.doi: 10.1038/nature14133
Probabilistic reanalysis of twentieth-century sea-level rise p.481
A statistical reassessment of the tide gauge record concludes that sea level rose at a rate of about 1.2 millimetres per year from 1901 to 1990, slightly lower than prior estimates and now consistent with estimates based on individual contributions to sea-level change; the estimates reported here from 1990 onwards are consistent with other work, suggesting that the recent acceleration in sea-level rise is greater than previously thought.doi: 10.1038/nature14093
A basal ichthyosauriform with a short snout from the Lower Triassic of China p.485
The Ichthyopterygia appeared in the fossil record as fully evolved, aquatic creatures, with nothing known about their transition from land to water, but now some light is shed on this transition by a fossil from the Lower Triassic of southern China of a small, primitive and possibly amphibious ichthyosaur-like creature, close to the common ancestry of ichthyosaurs and the obscure Hupehsuchia, a group of extinct aquatic reptiles known only from southern China.doi: 10.1038/nature13866
The mutational landscapes of genetic and chemical models of Kras-driven lung cancer p.489
Whole-exome sequencing is used to compare the mutational landscape of adenomas from three mouse models of non-small-cell lung cancer, induced either by exposure to carcinogens or by genetic mutation of Kras; the results reveal that the two types of tumour have different mutational profiles and adopt different routes to tumour development.doi: 10.1038/nature13898
Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis p.493
Endophilin-A2 (endoA2) is shown to mediate clathrin-independent endocytosis of Shiga and cholera toxins, and to function in parallel with dynamin and actin in the pulling-force-driven scission of Shiga-toxin-induced tubular structures.doi: 10.1038/nature14064
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth p.497
The mTORC1 complex has been implicated in tumorigenesis owing partially to its ability to increase protein translation; now, mTORC1 activity in the mouse intestine is shown not to be required for normal homeostasis but to be necessary for the triggering of tumorigenesis by APC mutations, suggesting that it could be a good target for the prevention of colorectal cancer in high-risk patients.doi: 10.1038/nature13896
IgG1 protects against renal disease in a mouse model of cryoglobulinaemia p.501
Here, the predominant murine immunoglobulin G subclass, IgG1, which is a poor activator of effector mechanisms, is shown to have a regulatory function, protecting against the development of IgG3 immune-complex-driven renal disease by competing with IgG3 for antigen and increasing immune complex solubility.doi: 10.1038/nature13868
Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution p.505
Human immunodeficiency virus type 1 (HIV-1) assembly proceeds in two stages. First, the 55 kilodalton viral Gag polyprotein assembles into a hexameric protein lattice at the plasma membrane of the infected cell, inducing budding and release of an immature particle. Second, Gag is cleaved by the viral protease, leading to internal rearrangement of the virus into the mature, infectious form
doi: 10.1038/nature13838
Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB p.509
Structural and biochemical studies show that the biosynthesis of the food preservative nisin involves the tRNA-dependent glutamylation of serine and threonine.doi: 10.1038/nature13888
Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation p.513
X-ray crystallography and EPR spectroscopy are used to characterize a soluble, oxygen-tolerant reductive dehalogenase from Nitratireductor pacific us pht-3B; the data suggest that the cobalt in the cobalamin cofactor ligates the halogen atom of the substrate, directly abstracting the halogen atom via an oxidative addition.doi: 10.1038/nature13901
