Volume 513 Issue 7518


A worthy ambition p.279

Finalizing the European Research Area is still a vibrant and relevant goal.

doi: 10.1038/513279b

Diversity challenge p.279

There is growing evidence that embracing diversity — in all its senses — is key to doing good science. But there is still work to be done to ensure that inclusivity is the default, not the exception.

doi: 10.1038/513279a

Amped-up plants p.280

Bacterial enzyme supercharges photosynthesis, promising increased yields for crops.

doi: 10.1038/513280a


News Features

Bounty hunters p.294

Destructive lionfish are invading coral reefs in the Americas, but fishing competitions can help to keep the problem species in check.

doi: 10.1038/513294a

Pride in science p.297

The sciences can be a sanctuary for gay, lesbian, bisexual and transgender individuals, but biases may still discourage many from coming out.

doi: 10.1038/513297a

News & Views

Radiating genomes p.318

Genome sequences and gene-expression data from representatives of five distinct lineages of African cichlid fish reveal signatures of the genomic changes that underlie the astounding cichlid diversity seen today. See Article p.375

doi: 10.1038/nature13742

Catching relativistic electrons p.319

Low-energy electrons have been found to mimic relativistic high-energy particles in cadmium arsenide. This defines the first stable '3D Dirac semimetal', which holds promise for fundamental-physics exploration and practical applications.

doi: 10.1038/513319a

The evolutionary roots of lethal conflict p.321

A comprehensive analysis of lethal coalitionary aggression in chimpanzees convincingly demonstrates that such aggression is an adaptive behaviour, not one that has emerged in response to human impacts. See Letter p.414

doi: 10.1038/513321a

Giant black hole in a stripped galaxy p.322

An oversized, supermassive black hole has been discovered at the centre of a densely packed conglomeration of stars. The finding suggests that the system is the stripped nucleus of a once-larger galaxy. See Letter p.398

doi: 10.1038/513322a

Shedding light on a change of mind p.323

Sophisticated genetic tools that make brain cells responsive to light have now been used in mice to trigger a memory connected with a particular place, and to switch its association from negative to positive, or vice versa. See Letter p.426

doi: 10.1038/nature13745

Reactivity tamed one bond at a time p.324

A catalyst that couples together three reactants to form just one compound out of several possibilities, as a single mirror-image isomer, should simplify the synthesis of biologically relevant molecules. See Article p.367

doi: 10.1038/513324a


Multifunctional organoboron compounds for scalable natural product synthesis p.367

A catalytic process is reported that begins with a highly selective copper–boron addition to a monosubstituted allene, and in which the resulting boron-substituted organocopper intermediate then participates in a chemoselective, site-selective and enantioselective allylic substitution; this approach is used in the enantioselective synthesis of gram quantities of two natural products.

doi: 10.1038/nature13735

The genomic substrate for adaptive radiation in African cichlid fish OPEN p.375

Genomes and transcriptomes of five distinct lineages of African cichlids, a textbook example of adaptive radiation, have been sequenced and analysed to reveal that many types of molecular changes contributed to rapid evolution, and that standing variation accumulated during periods of relaxed selection may have primed subsequent diversification.

doi: 10.1038/nature13726

Proteogenomic characterization of human colon and rectal cancer p.382

Proteome analysis of The Cancer Genome Atlas (TCGA) colorectal cancer specimens reveals that DNA- or RNA-level measurements cannot reliably predict protein abundance, colorectal tumours can be separated into distinct proteotypes, and that copy number alterations drive mRNA abundance changes but few extend to protein-level changes.

doi: 10.1038/nature13438

Molecular architecture and mechanism of the anaphase-promoting complex p.388

The anaphase-promoting complex/cyclosome (APC/C) is a large E3 ligase that mediates ubiquitin-dependent proteolysis of cell cycle regulatory proteins; here the complete secondary structure architecture of human APC/C complexed with its coactivator CDH1 and substrate HSL1 is determined at 7.4 Å resolution, revealing allosteric changes induced by the coactivator that enhance affinity for UBCH10–ubiqutin.

doi: 10.1038/nature13543


A supermassive black hole in an ultra-compact dwarf galaxy p.398

Dynamical modelling of the ultra-compact dwarf galaxy M60-UCD1 reveals the presence of a supermassive black hole; this suggests the object is a stripped galaxy nucleus and implies the existence of supermassive black holes in many other ultra-compact dwarf galaxies.

doi: 10.1038/nature13762

Spreading continents kick-started plate tectonics p.405

The slow gravitational collapse of early continents could have kick-started transient episodes of plate tectonics until, as the Earth’s interior cooled and oceanic lithosphere became heavier, plate tectonics became self-sustaining.

doi: 10.1038/nature13728