Volume 578 Number 7795

Editorials

News

News Features

News & Views

How to silence an X chromosome p.365

The non-coding RNA Xist has been shown to enlist the SPEN protein to recruit a team of protein complexes — initiating the process that prevents transcription of one of the two X chromosomes found in female mammalian cells.

doi: 10.1038/d41586-020-00207-0

Why surface roughness is similar at different scales p.366

Most surfaces are rough at many length scales. Simulations show that this characteristic originates at the atomic level in metal-based materials when smooth blocks of these materials are compressed.

doi: 10.1038/d41586-019-03952-z

30 years of the iron hypothesis of ice ages p.370

In 1990, an oceanographer who had never worked on climate science proposed that ice-age cooling has been amplified by increased concentrations of iron in the sea — and instigated an explosion of research.

doi: 10.1038/d41586-020-00393-x

Transfer of ubiquitin protein caught in the act p.372

A process termed ubiquitination mediates the regulated destruction of cellular proteins, thereby preventing disease or infection. Structural data now reveal how a crucial regulator of ubiquitination enzymes coordinates this process.

doi: 10.1038/d41586-020-00325-9

Articles