네이처 컨텐츠

Editorials

News

News Features

The future of work p.315

Digital technologies are upending the workforce. The right research can tell us how.

doi: 10.1038/550315a

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News & Views

Learning to play Go from scratch p.336

An artificial-intelligence program called AlphaGo Zero has mastered the game of Go without any human data or guidance. A computer scientist and two members of the American Go Association discuss the implications. See Article p.354

Satinder Singh, Andy Okun & Andrew Jackson

doi: 10.1038/550336a

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Bacterial snack attack deactivates a drug p.337

Tumour cells can develop intrinsic adaptations that make them less susceptible to chemotherapy. It emerges that extrinsic bacterial action can also enable tumour cells to escape the effects of drug treatment.

Christian Jobin

doi: 10.1038/550337a

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Data analysis meets quantum physics p.339

A technique that combines machine learning and quantum computing has been used to identify the particles known as Higgs bosons. The method could find applications in many areas of science. See Letter p.375

Steven Schramm

doi: 10.1038/550339a

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Genome jail-break triggers lockdown p.340

A pro-inflammatory response, the senescence-associated secretory phenotype, can affect development, ageing and cancer. It emerges that one trigger for this response is the presence of DNA in the cytoplasm. See Letter p.402

Neil T. Umbreit & David Pellman

doi: 10.1038/nature24146

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Complex assistance for DNA invasion p.342

Repair of broken DNA is vital for genome stability and to prevent the development of cancer. Research shows how the tumour-suppressor protein BRCA1 promotes a DNA-repair pathway called homologous recombination. See Article p.360

Petr Cejka

doi: 10.1038/nature24149

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Domains to the rescue for Rett syndrome p.343

Rett syndrome is a brain disorder caused by disrupted forms of the protein MECP2, but how MECP2 loss affects the brain is unknown. A mouse study now implicates key domains of the protein and offers therapeutic insights. See Letter p.398

Anne E. West

doi: 10.1038/nature24151

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Review

DNA sequencing at 40: past, present and future p.345

The history and future potential of DNA sequencing, including the development of the underlying technologies and the expansion of its areas of application, are reviewed.

Jay Shendure, Shankar Balasubramanian, George M. Church, Walter Gilbert, Jane Rogers, Jeffery A. Schloss & Robert H. Waterston

doi: 10.1038/nature24286

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Articles

Mastering the game of Go without human knowledge p.354

Starting from zero knowledge and without human data, AlphaGo Zero was able to teach itself to play Go and to develop novel strategies that provide new insights into the oldest of games.

David Silver, Julian Schrittwieser, Karen Simonyan, Ioannis Antonoglou, Aja Huang, Arthur Guez, Thomas Hubert, Lucas Baker, Matthew Lai, Adrian Bolton + et al.

doi: 10.1038/nature24270

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BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing p.360

The tumour suppressor complex BRCA1–BARD1, which facilitates the generation of a single-stranded DNA template during homologous recombination, also binds to the recombinase RAD51 and enhances its function.

Weixing Zhao, Justin B. Steinfeld, Fengshan Liang, Xiaoyong Chen, David G. Maranon, Chu Jian Ma, Youngho Kwon, Timsi Rao, Weibin Wang, Chen Sheng + et al.

doi: 10.1038/nature24060

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Letters

Ion sieving in graphene oxide membranes via cationic control of interlayer spacing p.380

Cations are used to control the interlayer spacing of graphene oxide membranes, enabling efficient and selective sieving of hydrated cations.

Liang Chen, Guosheng Shi, Jie Shen, Bingquan Peng, Bowu Zhang, Yuzhu Wang, Fenggang Bian, Jiajun Wang, Deyuan Li, Zhe Qian + et al.

doi: 10.1038/nature24044

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Organic long persistent luminescence p.384

A blend of two organic molecules excited by a simple LED light source can release the stored excitation energy slowly as ‘long persistent luminescence’ over periods of up to an hour.

Ryota Kabe & Chihaya Adachi

doi: 10.1038/nature24010

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Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex p.388

Interactions with male and female intruders activated overlapping neuronal populations in the ventromedial hypothalamus of inexperienced adult male mice, and these ensembles gradually separated as the mice acquired social and sexual experience with conspecifics.

Ryan Remedios, Ann Kennedy, Moriel Zelikowsky, Benjamin F. Grewe, Mark J. Schnitzer & David J. Anderson

doi: 10.1038/nature23885

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Establishment of mouse expanded potential stem cells p.393

Cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells, highlighting the feasibility of establishing expanded potential stem cells for other mammalian species.

Jian Yang, David J. Ryan, Wei Wang, Jason Cheuk-Ho Tsang, Guocheng Lan, Hideki Masaki, Xuefei Gao, Liliana Antunes, Yong Yu, Zhexin Zhu + et al.

doi: 10.1038/nature24052

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Radically truncated MeCP2 rescues Rett syndrome-like neurological defects p.398

Analysis of the minimal functional unit for MeCP2 protein shows that its function is to recruit the NCoR/SMRT co-repressor complex to methylated sites on chromatin, which may have use in designing strategies for gene therapy of Rett syndrome.

Rebekah Tillotson, Jim Selfridge, Martha V. Koerner, Kamal K. E. Gadalla, Jacky Guy, Dina De Sousa, Ralph D. Hector, Stuart R. Cobb & Adrian Bird

doi: 10.1038/nature24058

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Cytoplasmic chromatin triggers inflammation in senescence and cancer p.402

Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.

Zhixun Dou, Kanad Ghosh, Maria Grazia Vizioli, Jiajun Zhu, Payel Sen, Kirk J. Wangensteen, Johayra Simithy, Yemin Lan, Yanping Lin, Zhuo Zhou + et al.

doi: 10.1038/nature24050

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Enhanced proofreading governs CRISPR–Cas9 targeting accuracy p.407

A new engineered version of SpCas9, called HypaCas9, displays enhanced accuracy of editing without significant loss of efficiency at the desired target.

Janice S. Chen, Yavuz S. Dagdas, Benjamin P. Kleinstiver, Moira M. Welch, Alexander A. Sousa, Lucas B. Harrington, Samuel H. Sternberg, J. Keith Joung, Ahmet Yildiz & Jennifer A. Doudna

doi: 10.1038/nature24268

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Structure of mammalian endolysosomal TRPML1 channel in nanodiscs p.415

The structure of mouse transient receptor potential mucolipin 1 (TRPML1), a cation channel located within endosomal and lysosomal membranes, is resolved using single-particle electron cryo-microscopy.

Qingfeng Chen, Ji She, Weizhong Zeng, Jiangtao Guo, Haoxing Xu, Xiao-chen Bai & Youxing Jiang

doi: 10.1038/nature24035

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