AI diagnostics need attention p.285

Computer algorithms to detect disease show great promise, but they must be developed and applied with care.

doi: 10.1038/d41586-018-03067-x


How Putin can restore Russian research p.285

The sleeping bear of Russian science could finally wake — and China can show it how.

doi: 10.1038/d41586-018-03066-y


Everyone needs a data-management plan p.286

They sound dull, but data-management plans are essential, and funders must explain why.

doi: 10.1038/d41586-018-03065-z



AI researchers embrace Bitcoin technology to share medical data p.293

Blockchain could let people offer health records for research — without losing control over them.

doi: 10.1038/d41586-018-02641-7


MIT launches multimillion-dollar collaboration to develop fusion energy p.294

With corporate participation, researchers seek to build a pilot fusion energy plant within 15 years.

doi: 10.1038/d41586-018-02966-3


Drilling project probes New Zealand’s risk of killer quakes p.295

Major expedition will investigate enigmatic sea-floor fault zone.

doi: 10.1038/d41586-018-02640-8


Police probe of Brazilian marijuana researcher sparks protests p.296

Researchers are concerned about potential restrictions to academic freedom.

doi: 10.1038/d41586-018-02842-0


Russian science chases escape from mediocrity p.297

With Vladimir Putin set to earn another presidential term, researchers wonder whether his government will reverse decades of decline.

doi: 10.1038/d41586-018-02872-8

News Features


What lava lamps and vinaigrette can teach us about cell biology p.300


doi: 10.1038/d41586-018-03070-2

News & Views


Earth science: Oxidation softens mantle rocks p.314


doi: 10.1038/d41586-018-02828-y


Neuroscience: Questioning human neurogenesis p.315


doi: 10.1038/d41586-018-02629-3


Cancer genomics: Landscapes of childhood tumours p.316


doi: 10.1038/d41586-018-01648-4


Condensed-matter physics: Waves cornered p.318


doi: 10.1038/d41586-018-02868-4


Immunology: Melanin triggers antifungal defences p.319


doi: 10.1038/d41586-018-02370-x



The landscape of genomic alterations across childhood cancers OPEN p.321

Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

doi: 10.1038/nature25480


The atomic structure of a eukaryotic oligosaccharyltransferase complex p.328

The high-resolution structure of the entire eukaryotic oligosaccharyltransferase complex is determined, revealing the role of membrane lipids in mediating inter-subunit interactions, and the mechanism by which the complex enables protein N-glycosylation.

doi: 10.1038/nature25755



Two chemically similar stellar overdensities on opposite sides of the plane of the Galactic disk p.334

Fourteen stars from stellar overdensities above and below the Galactic disk have the same elemental abundances as disk stars, suggesting that these stars originated in the disk, perhaps being removed during interaction with passing dwarf galaxies.

doi: 10.1038/nature25490


Confocal non-line-of-sight imaging based on the light-cone transform p.338

A confocal scanning technique solves the reconstruction problem of non-line-of-sight imaging to give fast and high-quality reconstructions of hidden objects.

doi: 10.1038/nature25489


Observation of a phononic quadrupole topological insulator p.342

A two-dimensional phononic quadrupole topological insulator is demonstrated experimentally using mechanical metamaterials, which has both the one-dimensional edge states and the zero-dimensional corner states predicted by theory.

doi: 10.1038/nature25156


A quantized microwave quadrupole insulator with topologically protected corner states p.346

A quantized quadrupole topological insulator composed of capacitively coupled microwave resonators has corner states that are protected by bulk topology and exhibit exceptional robustness against edge deformation.

doi: 10.1038/nature25777


High-resolution magnetic resonance spectroscopy using a solid-state spin sensor p.351

High-resolution nuclear magnetic resonance spectroscopy at the scale of single cells is achieved by combining a magnetometer consisting of an ensemble of nitrogen–vacancy centres with a narrowband synchronized readout protocol.

doi: 10.1038/nature25781


Redox-influenced seismic properties of upper-mantle olivine p.355

Redox conditions and associated defect chemistry rather than water content, as previously thought, strongly influence the seismic properties of olivine, the main constituent mineral of Earth’s upper mantle.

doi: 10.1038/nature25764


Altruism in a volatile world p.359

A derivation of Hamilton’s rule that considers explicit environmental stochasticity can predict when organisms should pay a cost to influence the variance in the reproductive success of their relatives, formalizing the link between bet-hedging and altruism.

doi: 10.1038/nature25965


Pursuing sustainable productivity with millions of smallholder farmers p.363

Millions of Chinese smallholder farmers were persuaded to adopt enhanced management practices, which led to a greater yield, reduced nitrogen fertilizer use and improved environmental performance throughout China.

doi: 10.1038/nature25785


Pervasive phosphorus limitation of tree species but not communities in tropical forests p.367

In lowland tropical forests in Panama, widespread species-level phosphorus limitation of tree growth is not reflected in community-wide growth or biomass owing to the presence of a few species tolerant of low phosphorus availability.

doi: 10.1038/nature25789


Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours OPEN p.371

Analysis of the genomes, exomes and transcriptomes of 1,699 childhood cancers identifies 142 driver genes.

doi: 10.1038/nature25795


Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults p.377

Recruitment of young neurons to the hippocampus decreases rapidly during the first years of life, and neurogenesis does not continue, or is extremely rare, in the adult human brain.

doi: 10.1038/nature25975


Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus p.382

The C-type lectin receptor MelLec recognizes DHN-melanin in conidial spores of Aspergillus fumigatus and other DHN-melanized fungi, revealing an important role for this receptor in antifungal immunity in both mice and humans.

doi: 10.1038/nature25974


EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma p.387

The EWS–FLI1 fusion protein, expressed in Ewing sarcoma, increases global transcription, causes accumulation of R loops and replication stress, and impairs BRCA1-mediated repair.

doi: 10.1038/nature25748


Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte p.392

Gonadal germline epigenetic reprogramming involves an interplay between DNA methylation, the polycomb complex and Tet1 in both DNA methylation dependent and independent roles, to ensure the activation of a specific subset of genes critical for progression of gametogenesis.

doi: 10.1038/nature25964


Gating mechanisms of acid-sensing ion channels p.397

X-ray and cryo-electron microscopy structures of the acid-sensing ion channel ASIC1a reveal the molecular mechanisms of channel gating and desensitization.

doi: 10.1038/nature25782

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