Non-expert nation p.589

Scientists — just like everybody else — have little idea what will happen now that the United Kingdom has voted to exit the European Union.

doi: 10.1038/534589a


The big picture p.589

Problems of modern society demand collaborative research.

doi: 10.1038/534589b


Calculated risks p.590

The perils of the past must not be allowed to happen again

doi: 10.1038/534590a



UK scientists in limbo after Brexit shock p.597

Researchers organize to lobby for science as country prepares for life outside the EU.

doi: 10.1038/534597a


NASA’s Juno spacecraft prepares to probe Jupiter’s mysteries p.599

The mission will peek through the gas giant’s swirling clouds in search of a planetary core.

doi: 10.1038/534599a


Stressed Indus River threatens Pakistan’s water supplies p.600

Cooler, cloudier summers slow snowmelt in Himalayas

doi: 10.1038/534600a


ArXiv preprint server plans multimillion-dollar overhaul p.602

Users urge caution in revamp of service at the heart of physics.

doi: 10.1038/534602a

News Features


Dolly at 20: The inside story on the world’s most famous sheep p.604


doi: 10.1038/534604a


Why ultra-powerful radio bursts are the most perplexing mystery in astronomy p.610


doi: 10.1038/534610a

News & Views


Microbiology: The dark side of antibiotics p.624


doi: 10.1038/nature18449


Physiology: Stressed-out chromatin promotes longevity p.625


doi: 10.1038/534625a


Earth science: An extended yardstick for climate variability p.626


doi: 10.1038/534626a


Cancer: Transmissible tumours under the sea p.628


doi: 10.1038/nature18455



Paris Agreement climate proposals need a boost to keep warming well below 2 °C p.631

The objective of the Paris climate agreement is to limit global-average temperature increase to well below 2 degrees Celsius above pre-industrial levels and to further pursue limiting it to 1.5 degrees Celsius; here, the adequacy of the national plans submitted in preparation for this agreement is assessed, and it is concluded that substantial enhancement or over-delivery on these plans is required to have a reasonable chance of achieving the Paris climate objective.

doi: 10.1038/nature18307



The Asian monsoon over the past 640,000 years and ice age terminations p.640

Records of the Asian monsoon have been extended to 640,000 years ago, and confirm both that the 100,000-year ice age cycle results from integral numbers of precessional cycles and that insolation influences the pacing of major millennial-scale climate events.

doi: 10.1038/nature18591


A combinatorial strategy for treating KRAS-mutant lung cancer p.647

A systematic screen identifies FGFR1 signalling reactivation as an adaptive resistance mechanism after MEK inhibition specific for KRAS tumours, which can be targeted by combined inhibition with the clinically approved drugs trametinib and ponatinib.

doi: 10.1038/nature18600


The landscape of accessible chromatin in mammalian preimplantation embryos p.652

An improved ATAC-seq approach is used to describe a genome-wide view of accessible chromatin and cis-regulatory elements in mouse preimplantation embryos, allowing construction of a regulatory network of early development that helps to identify key modulators of lineage specification.

doi: 10.1038/nature18606



A Neptune-sized transiting planet closely orbiting a 5–10-million-year-old star p.658

A fully formed, Neptune-sized planet is observed orbiting a young star, demonstrating that planets can form in less than 10 million years and may also experience inward migration on these timescales.

doi: 10.1038/nature18293


A hot Jupiter orbiting a 2-million-year-old solar-mass T Tauri star p.662

The radial velocities of a young star are measured, revealing the presence of a planet of mass about three-quarters that of Jupiter, orbiting its host star very closely, and thus demonstrating that ‘hot Jupiters’ can migrate inwards in less than two million years.

doi: 10.1038/nature18305


Tunable two-dimensional arrays of single Rydberg atoms for realizing quantum Ising models p.667

Many proof-of-principle platforms for quantum simulation of spin models have been implemented, but it is difficult to produce a design with sufficient flexibility to realize arbitrary geometries and variable distance; here a platform based on arrays of optical microtraps achieves this flexibility with large atom numbers.

doi: 10.1038/nature18274


Synthetic Landau levels for photons p.671

It is an long-standing goal to produce a photonic quantum Hall effect, analogous to the well-known quantum Hall effect for electrons; now an artificial magnetic field for a continuum of photons has been produced, making it possible to observe photonic Landau levels in a photonic quantum Hall material.

doi: 10.1038/nature17943


Switching stiction and adhesion of a liquid on a solid p.676

Switching of static friction and adhesion of a liquid drop on a corrugated solid boron nitride surface is linked to the intercalation of hydrogen, which changes the electric field of in-plane dipole rings and thus reduces the adsorption energy.

doi: 10.1038/nature18275


Seasonality of temperate forest photosynthesis and daytime respiration p.680

Climate models require an understanding of ecosystem-scale respiration and photosynthesis, yet there is no way of measuring these two fluxes directly; here, new instrumentation is used to determine these fluxes in a temperate forest, showing, for instance, that respiration is less during the day than at night.

doi: 10.1038/nature17966


Interdisciplinary research has consistently lower funding success p.684

The degree of interdisciplinarity in research proposals negatively correlates with funding success across a wide range of research fields.

doi: 10.1038/nature18315


Basal forebrain projections to the lateral habenula modulate aggression reward p.688

Here, the circuits underlying the motivational or rewarding component to aggression are deconstructed, showing that an inhibitory projection from the basal forebrain to the lateral habenula bi-directionally controls this aspect of aggression.

doi: 10.1038/nature18601

微生物遺伝学:maximum-depth sequencingにより明らかになった細菌の変異率と変異誘発機構

Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing p.693

Maximum-depth sequencing (MDS), a new method of detecting extremely rare variants within a bacterial population, is used to show that mutation rates in Escherichia coli vary across the genome by at least an order of magnitude, and also to uncover mechanisms of antibiotic-induced mutagenesis.

doi: 10.1038/nature18313


Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion p.697

Antibiotic usage in humans can increase the risk of Salmonella infection by an unknown mechanism; this paper reveals that the antibiotic streptomycin increases the activity of the host-encoded enzyme inducible nitric oxide synthase, this then drives Salmonella expansion by the generation of galactarate — a metabolite normally absent from the gut.

doi: 10.1038/nature18597


Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis p.700

A complex interplay involving Notch- and Erbb2-mediated signalling between cardiomyocytes guides the morphogenesis of the ventricular wall.

doi: 10.1038/nature18310


Widespread transmission of independent cancer lineages within multiple bivalve species p.705

Disseminated neoplasias in three species of bivalve mollusc are attributed to transmissible clonal lines, and neoplasias in one species are caused by cross-species transmission of cancer, suggesting that transmissible neoplasia is common in marine species.

doi: 10.1038/nature18599


Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation p.710

Acute protein folding stress in the mitochondrial matrix activates both increased chaperone availability within the matrix and reduced matrix-localized protein synthesis through translational inhibition.

doi: 10.1038/nature18302

分子生物学:H4K20me0は複製後クロマチンを標識し、TONSL–MMS22L DNA修復複合体を誘導する

H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex p.714

We have a limited understanding of how cells mark and identify newly replicated genomic loci that have a sister chromatid; here, unmethylated K20 in the tail of new histone H4 is shown to serve as a signature of post-replicative chromatin, which is specifically recognized by the homologous recombination complex TONSL–MMS22L.

doi: 10.1038/nature18312


Translation readthrough mitigation p.719

Translation termination sequences are occasionally bypassed by the ribosome and the resulting proteins can be detrimental to the cell; here it is shown that cells can prevent such proteins from accumulating through peptides that are encoded within the 3' UTR of genes in both humans and C. elegans.

doi: 10.1038/nature18308


Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution p.724

The first high-resolution structure of a human actomyosin complex reveals the interface between F-actin and myosin in near-atomic detail.

doi: 10.1038/nature18295

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