Renewed energy p.7

Reforms at the US Department of Energy are recharging research.

doi: 10.1038/510007b


Don’t feed the trolls p.7

Patent abuse slows down research and innovation, and must be confronted. Delays to US legislation are not reassuring, but there has been some progress in the courts.

doi: 10.1038/510007a


Integrity mentors p.8

Policies in Ireland and China make Nature’s 2014 mentoring awards timely.

doi: 10.1038/510008a



Phage therapy gets revitalized p.15

The rise of antibiotic resistance rekindles interest in a century-old virus treatment.

doi: 10.1038/510015a


Land models put to climate test p.16

Study under way on Mongolian steppes aims to improve knowledge of warming effects on vegetation.

doi: 10.1038/510016a


Funding windfall rescues abandoned stem-cell trial p.18

But more players have joined the quest to treat spinal-cord injury with embryonic cells.

doi: 10.1038/510018a


Federal boost for German science p.19

Agreement on changes to constitution pave way for university funding shake-up.

doi: 10.1038/510019a


Big Bang finding challenged p.20

Signal of gravitational waves was too weak to be significant, studies suggest.

doi: 10.1038/510020a

News Features


Solar energy: Springtime for the artificial leaf p.22


doi: 10.1038/510022a


Alzheimer's disease: The forgetting gene p.26


doi: 10.1038/510026a

News & Views


Evolutionary biology: Excitation over jelly nerves p.38


doi: 10.1038/nature13340


Climate science: How Antarctic ice retreats p.39


doi: 10.1038/nature13345


Cell biology: Short RNAs and shortness of breath p.40


doi: 10.1038/510040a


Astrophysics: The MAD world of black holes p.42

可視光観測と電波観測の結果の解析から、活動銀河の中心部から強力なジェットが噴き出す仕組みが明らかにされた。こうした銀河の中心部では、超大質量ブラックホールがMAD(magnetically arrested disk)を介して物質を降着しているのである。

doi: 10.1038/510042a


Hepatitis C: Treatment triumphs p.43


doi: 10.1038/510043a


Neurological disorders: Quality-control pathway unlocked p.44


doi: 10.1038/510044a



Accurate design of co-assembling multi-component protein nanomaterials p.103

A computational method is reported that can be used to design protein nanomaterials in which two distinct subunits co-assemble into a specific architecture; five 24-subunit cage-like protein nanomaterials are designed, and experiments show that their structures are in close agreement with the computational design models.

doi: 10.1038/nature13404


The ctenophore genome and the evolutionary origins of neural systems OPEN p.109

The draft genome of the ctenophore Pleurobrachia bachei (Pacific sea gooseberry) is presented, together with ten other ctenophore transcriptomes — these genomes have a very different neurogenic, immune and developmental gene content when compared with other animal genomes, and it is proposed that ctenophore neural systems, and possibly muscle specification, evolved independently from those in other animals.

doi: 10.1038/nature13400


miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110 p.115

Loss-of-function studies of the miR-34/449 microRNA family in mouse and Xenopus reveal their evolutionarily conserved role in ciliogenesis by repressing expression of the centriolar protein Cp110.

doi: 10.1038/nature13413


Crystal structure of the human glucose transporter GLUT1 p.121

The structure of human GLUT1 in an inward-open conformation is reported; access to the structure of the human protein, instead of just a bacterial homologue, made it possible to map (inactivating) mutations associated with GLUT1 deficiency syndrome onto the structure.

doi: 10.1038/nature13306



Dynamically important magnetic fields near accreting supermassive black holes p.126

A study of 76 radio-loud active galaxies shows that the magnetic field in the bipolar jet that emanates from each galaxy is tightly correlated with the luminosity of the accretion disk; the jet-launching regions of these galaxies are therefore thought to be threaded by dynamically important magnetic fields that will affect the properties of the accretion disks.

doi: 10.1038/nature13399


Palladium-catalysed C–H activation of aliphatic amines to give strained nitrogen heterocycles p.129

A palladium-catalysed C–H bond activation process is reported that proceeds through a four-membered-ring cyclopalladation pathway; it allows a methyl group that is adjacent to an unprotected secondary amine to be transformed into a synthetically versatile nitrogen heterocycle.

doi: 10.1038/nature13389


Millennial-scale variability in Antarctic ice-sheet discharge during the last deglaciation p.134

Two well-dated, high-resolution records of iceberg-rafted debris are presented that document variability in Antarctic Ice Sheet discharge during the last deglaciation.

doi: 10.1038/nature13397


Increasing CO2 threatens human nutrition p.139

The largest assemblage so far of published data shows that C3 crops have decreased zinc and iron levels under CO2 conditions predicted for the middle of this century, with worldwide nutritional implications.

doi: 10.1038/nature13179


Coordination of entorhinal–hippocampal ensemble activity during associative learning p.143

Simultaneous recordings from hippocampus and entorhinal cortex in rats show that as the animals learn odour guidance cues during their exploration of two-dimensional space in the laboratory, ensembles of coherently firing neurons emerge in both locations, with cortical–hippocampal oscillatory coupling occurring in a specific range of the beta-gamma frequency band.

doi: 10.1038/nature13162

微生物学:通性メタン酸化細菌Methylocella silvestrisの微量ガス代謝の多能性

Trace-gas metabolic versatility of the facultative methanotroph Methylocella silvestris p.148

The climate-active gas methane is generated both by biological processes and by thermogenic decomposition of fossil organic material, which forms methane and short-chain alkanes, principally ethane, propane and butane. In addition to natural sources, environments are exposed to anthropogenic inputs of all these gases from oil and gas extraction and distribution. The gases provide carbon and/or energy for a diverse range of microorganisms that can metabolize them in both anoxic and oxic zones. Aerobic methanotrophs, which can assimilate methane, have been considered to be entirely distinct from utilizers of short-chain alkanes, and studies of environments exposed to mixtures of methane and multi-carbon alkanes have assumed that disparate groups of microorganisms are responsible for the metabolism of these gases. Here we describe the mechanism by which a single bacterial strain, Methylocella silvestris, can use methane or propane as a carbon and energy source, documenting a methanotroph that can utilize a short-chain alkane as an alternative to methane. Furthermore, during growth on a mixture of these gases, efficient consumption of both gases occurred at the same time. Two soluble di-iron centre monooxygenase (SDIMO) gene clusters were identified and were found to be differentially expressed during bacterial growth on these gases, although both were required for efficient propane utilization. This report of a methanotroph expressing an additional SDIMO that seems to be uniquely involved in short-chain alkane metabolism suggests that such metabolic flexibility may be important in many environments where methane and short-chain alkanes co-occur.

doi: 10.1038/nature13192


Focused specificity of intestinal TH17 cells towards commensal bacterial antigens p.152

Segmented filamentous bacteria drive the acquisition of the TH17 phenotype in an antigen-specific manner; these findings begin to elucidate how gut-induced TH17 cells can contribute to distal organ-specific autoimmune disease.

doi: 10.1038/nature13279


Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation p.157

In mice, it is possible to induce a psoriasis-like condition by applying imiquimod; here, the production of interleukin-23 that is stimulated by such skin inflammation is shown to depend on the interaction of nociceptors expressing the Nav1.8 and TRPV1 channels with skin-resident dendritic cells.

doi: 10.1038/nature13199


Ubiquitin is phosphorylated by PINK1 to activate parkin p.162

Ubiquitin, known for its role in post-translational modification of other proteins, undergoes post-translational modification itself; after a decrease in mitochondrial membrane potential, the kinase enzyme PINK1 phosphorylates ubiquitin at Ser 65, and the phosphorylated ubiquitin then interacts with ubiquitin ligase (E3) enzyme parkin, which is also phosphorylated by PINK1, and this process is sufficient for full activation of parkin enzymatic activity.

doi: 10.1038/nature13392


Oncogene-like induction of cellular invasion from centrosome amplification p.167

Cancer cells often have extra centrosomes, a paradox considering the detrimental effect extra centrosomes usually have on cell division; a study of human cells reveals that extra centrosomes can promote cancer cell invasion phenotypes through a pathway involving increased microtubule nucleation and Rac1 activity.

doi: 10.1038/nature13277


Membrane proteins bind lipids selectively to modulate their structure and function p.172

A new mass-spectrometry method has been developed to obtain high-resolution spectra of folded proteins bound to lipids; using this technique as well as X-ray crystallography provides evidence for membrane protein conformational change as a result of lipid–protein interaction.

doi: 10.1038/nature13419

「Journal home」に戻る