Genetic variants associated with susceptibility to prostate cancer in a Japanese population are reported this week in Nature Genetics. This represents the first genome-wide association study for prostate cancer in an Asian population, and finds evidence for both shared and distinct susceptibility variants between European and Asian populations.
Prostate cancer is one of the leading causes of cancer deaths, and shows an increasing incidence in Asian populations. Hidewaki Nakagawa and colleagues report a genome-wide association and replication study for prostate cancer in a total of 4,584 Japanese men and 8,801 healthy controls. They identify five genomic regions associated with prostate cancer that have not previously been identified in similar studies in European populations.