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Nature Immunology

May 18, 2009

Interleukin 17 (IL-17)-a soluble factor thought to promote inflammation and autoimmunity-can actually suppress the onset of inflammatory bowel disease, shows a paper published online in this week’s Nature Immunology.

Previous work documented high concentrations of IL-17 and interferon-gamma, another cytokine implicated in inflammation and autoimmunity, in colon tissue of humans with Crohn’s disease and mice with colitis.

Using a mouse model of colitis in which immune cells called T cells initiate disease, Richard Flavell and colleagues note that T cells lacking IL-17 or the IL-17 receptor induced more severe colitis than T cells able to produce and respond to IL-17. IL-17-deficient T cells also released more interferon-gamma.

These findings suggest net effects of IL-17 may be pro- or anti-inflammatory, and likely depend on the tissue and environment being examined.

DOI:10.1038/ni.1736 | Original article

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