The genome of a chronic hepatitis C (CHC) tumor that tested positive for hepatitis C virus (HCV), as well as a genetic risk locus for HCV-induced HCC, are reported in two independent studies in this week’s Nature Genetics.
More than 170 million people in the world are infected with hepatitis C virus. HCV infection leads to chronic hepatitis C, and consequently liver cirrhosis and hepatocellular carcinoma (HCC).
Tatsuhiro Shibata and colleagues sequenced a primary HCV-positive HCC tumor and matched normal cells from a Japanese male. They identified thousands of tumor-specific mutations. Koichi Matsuda and colleagues performed a genome-wide analysis of 1394 individuals of Japanese ancestry with HCV-induced HCC. The authors identified a locus on chromosome 6p21 that is strongly associated with HCV-induced HCC.