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Variants associated with polycystic ovary syndromeAdd to my bookmarks

Nature Genetics

December 13, 2010

Three genetic loci that are associated with risk of polycystic ovary syndrome are identified in this week’s issue of Nature Genetics.

Polycystic ovary syndrome (PCOS) causes many small cysts in the ovaries and affects fertility. PCOS affects approximately six to ten percent of women of reproductive age and leads to hormonal imbalance. If untreated, PCOS may lead to diabetes and heart disease.

Zi-Jiang Chen and colleagues analyzed the genomes of 4082 PCOS patients of Han Chinese ancestry. They identify three genetic loci that are associated with risk of PCOS on chromosomes 2p16.3, 2p21, and 9q33.3.

DOI:10.1038/ng.732 | Original article

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