Research Press Release

Variants associated with kidney cancer

Nature Genetics

December 6, 2010

Two genetic loci are associated with renal cell carcinoma (RCC), according to a new report published online this week in Nature Genetics. These are the first common genetic variants associated with this type of cancer.

Approximately 200,000 new cases of kidney cancer are diagnosed worldwide each year, with renal cell carcinoma accounting for 90% of all kidney cancer cases. High blood pressure, obesity and smoking are all risk factors for kidney cancer, although previously no common genetic variants were known to increase risk for the disease.

Paul Brennan, Stephen Chanock, and colleagues now report the first genome-wide analysis of 5,970 individuals with renal cell carcinoma. The study identifies two genetic loci that are associated with RCC risk.

DOI:10.1038/ng.723 | Original article

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