Research Highlights

doi:10.1038/nindia.2010.90 Published online 7 July 2010

Herpes virus co-infection in HIV cases

Human immunodeficiency virus (HIV) infection is associated with an increased risk for human herpesviruses (HHVs) and related diseases. These diseases frequently cause disease deterioration and therapeutic failures.

Researchers have found in samples of HIV infected patients the relative serum antibodies against CytoMegaloVirus (CMV),Herpes Simplex Virus type 2 (HSV-2), Varicella Zoster Virus (VZV), and Epstein Barr Virus (EBV-1). This would help in creating better methods for limiting the transmission of HHV.

The researchers analyzed the seroprevalence of HHV (CMV, HSV 2, EBV-1, VZV) antibodies and evaluated their association with age, sex and other demographic and behavioral factors.

Two hundred HIV positive patients from eastern India were screened for antibodies to the respective viruses using the indirect ELISA in triplicates.

In HIV-infected patients, serum antibodies against CytoMegaloVirus (CMV),Herpes Simplex Virus type 2 (HSV-2), Varicella Zoster Virus (VZV), and Epstein Barr Virus (EBV-1) were detected in 49 %, 47%, 32.5%, and 26% respectively.

The study contributed baseline data and provided insights into HIV co-infection.


References

  1. Chakraborty, N. et al. Incidence of multiple Herpesvirus infection in HIV seropositive patients, a big concern for Eastern Indian scenario. Virol. J. 7, 147 (2010) | Article | PubMed