Nature Hot Topic

Perseanol synthesised

(+)-Perseanol is an isoryanodane diterpene isolated from Persea indica. While somewhat similar to ryanodine, it's central ring system requires a different synthetic strategy. Here, Sarah Reisman and colleagues report the total synthesis of (+)-perseanol in 16 steps from commercially-available (R)-pulegone. The synthetic route involves an efficient annulation to form the tetracyclic core and which should be applicable to other similarly-structured diterpenes. Through synthesis of other isoryanodanes by this method the authors aim to investigate antifeedant and insecticidal properties and, importantly, selective activity in insects.

Nature 573, 7775 table of contents

Top Ten Highlights

Sign up for Nature Research e-alerts to get the lastest research in your inbox every week.

More Hot Topics

PrivacyMark System