Gou Young Koh, Ji Hoon Ahn and colleagues reveal in Nature that macromolecules from the cerebrospinal fluid (CSF) exit the central nervous system via meningeal lymphatic vessels (mLVs) at the base of the skull. They visualise the distinct anatomic location of these lymphatic vessels and identify specific morphologic features that facilitate CSF uptake and drainage. Furthermore, the authors show that integrity of mLVs and drainage of CSF is impaired with age. If these findings extend from mice to humans they are expected to provide further insights in neuropathophysiologic processes associated with ageing.
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