A two-photon fluorescence microscopy study of rats with experimental autoimmune encephalomyelitis — a model for multiple sclerosis — shows autoimmune-disease-triggering blood T cells first directly attaching and then scanning the internal surface of the spinal meningeal vasculature, sometimes crawling against the direction of blood flow. Once across the blood–brain barrier, the T cells engage with antigen-presenting phagocytes that in turn stimulate their further differentiation and tissue infiltration. The structures involved in these interactions with T cells could be potential candidate targets for therapy against autoimmune brain disease.
- (News & Views p41, doi: 10.1038/462041a)
- Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions (Letter p94, doi: 10.1038/nature08478)
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