Efficient homing of therapeutic T cells to the brain is a barrier to the success of brain tumour immunotherapy. The authors define how brain tumours regulate immune cell adhesion pathways to endothelial cells to promote immune evasion, and design a homing system to improve T cell trafficking to the brain. Engineering of T cell ligands to optimize adhesion and downstream steps for transmigration shows potential to improve the homing and anti-tumor activity of therapeutic T cells in brain tumours.
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