Nearly half of all deafness cases arise from genetic factors, yet there are limited treatment options available for inherited hearing loss. David Liu and colleagues develop a genome-editing approach to target a dominantly inherited form of deafness. In a mouse model of human deafness, CRISPR–Cas9 editing can disrupt the mutant allele and reduce hearing loss. The results support the potential utility of protein–RNA complex delivery in post-mitotic cells as a gene-editing strategy for some autosomal-dominant diseases.
- Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents (Letter p217, doi: 10.1038/nature25164)
- An ode to gene edits that prevent deafness (News & Views p162, doi: 10.1038/d41586-017-08645-z)
Recent Hot Topics
- Sep 13Effect of rising sea levels on coastal wetlands
- Sep 6Sub-lethal effects of sulfoximine pesticides on bumblebees
- Aug 30Forecasting the locations of earthquake aftershocks
- Aug 23Splicing together a lineage from snapshots
- Aug 16Reducing yeast chromosome numbers has only minor effect on cell fitness
Sign up for Nature Research e-alerts to get the lastest research in your inbox every week.