In the skin, epithelial stem cells form a barrier against environmental damage. Shruti Naik et al. now show that after acute inflammation, epithelial stem cells retains a memory that hastens barrier restoration during subsequent tissue damage. However, the increased sensitivity to further insults may also increase tissue damage and susceptibility to other disorders such as autoimmune diseases and cancer.
- Memory beyond immunity (News & Views p460, doi: 10.1038/nature24154)
- Inflammatory memory sensitizes skin epithelial stem cells to tissue damage (Article p475, doi: 10.1038/nature24271)
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