Based on its symptoms, schizophrenia has been considered a discrete disease, and yet genome-wide association studies for copy number variations (CNVs) associated with the disease have revealed that some CNVs confer high relative risk of schizophrenia but also of other psychiatric disorders. But CNVs can affect several genes. Now, a genome-wide association of single nucleotide polymorphisms (SNPs) using data from several large genome-wide scans reveals significant associations to individual loci that implicate immunity, brain development, memory and cognition in predisposition to schizophrenia.
- Common variants on chromosome 6p22.1 are associated with schizophrenia (Letter p753, doi: 10.1038/nature08192)
- Common variants conferring risk of schizophrenia (Letter p744, doi: 10.1038/nature08186)
- Common polygenic variation contributes to risk of schizophrenia and bipolar disorder (Letter p748, doi: 10.1038/nature08185)
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