Targeting premalignant pancreatic lesions before they progress to pancreatic ductal adenocarcinoma is challenging. Tannishtha Reya and colleagues have found that the stem cell factor encoding for the RNA-binding protein Musashi (Msi) is critical to this progression in genetic mouse models and patient-derived xenografts. They used an image-based approach to follow the cells as they progress to malignancy, and show that the growth of pancreatic tumours can be halted by targeting Msi with antisense oligonucleotides.
- Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma (Letter p407, doi: 10.1038/nature17988)
Recent Hot Topics
Sign up for Nature Research e-alerts to get the lastest research in your inbox every week.