Targeting premalignant pancreatic lesions before they progress to pancreatic ductal adenocarcinoma is challenging. Tannishtha Reya and colleagues have found that the stem cell factor encoding for the RNA-binding protein Musashi (Msi) is critical to this progression in genetic mouse models and patient-derived xenografts. They used an image-based approach to follow the cells as they progress to malignancy, and show that the growth of pancreatic tumours can be halted by targeting Msi with antisense oligonucleotides.
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