The properties of blood platelets — small discoid cells that carry out a broad range of functions related to haemostasis — marks them out as prime candidates to form the basis of drug delivery systems. These authors report a new nanoparticle-based delivery platform, in which polymeric nanoparticles are enclosed in the plasma membrane of human platelets. They demonstrate the use of these platelet-membrane cloaked nanoparticles for antibiotic delivery in murine models for cardiovascular disease and systemic bacterial infection.
- Platelet mimicry (News & Views p47, doi: 10.1038/nature15218)
- Nanoparticle biointerfacing by platelet membrane cloaking (Letter p118, doi: 10.1038/nature15373)
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