Genetic variants associated with Alzheimer’s disease are reported in a study published this week in Nature Genetics.
Philippe Amouyel and colleagues conducted a large scale association analysis, starting with a genome-wide association study including 17,008 individuals with Alzheimer’s and 37,154 healthy controls, followed by a second stage study including an additional 8,572 cases of the disease and 11,312 controls. In addition to the well-established association at the APOE locus, they identified 19 genomic regions significantly associated with late-onset Alzheimer’s disease, 11 of which are new susceptibility loci. Their findings reinforce pathways previously implicated in Alzheimer’s disease pathology, including immune response, inflammation, cell migration and lipid transport pathways. They also suggest new candidate genes and pathways that may be involved in disease risk.