Research highlight

Variants associated with schizophrenia

Nature Genetics

August 26, 2013

Genetic variants associated with schizophrenia are reported in a study published this week in Nature Genetics.

Patrick Sullivan and colleagues report a multi-stage genome-wide association study for schizophrenia, including 5,001 cases and 6,243 healthy controls from Sweden, as well 8,832 cases and 12,067 controls from international studies within the Psychiatric Genomics Consortium.They identify 22 genomic regions associated with schizophrenia; 13 of these are new and one of these was previously found to be associated with bipolar disorder. Their analysis of candidate genes at these regions suggests a role for neuronal calcium-channel signaling pathways in susceptibility to schizophrenia.

doi: 10.1038/ng.2742

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