Variants associated with dementia
Nature Genetics
February 15, 2010
A common genetic variant is associated with frontotemporal lobar degeneration (FTLD), a common cause of dementia, according to a study published online this week in Nature Genetics.
FTLD is characterized by the progressive degeneration of specific areas of the brain, along with progressive deficits in behavior and language. Fifty-percent of patients diagnosed with this disease have a specific form called FTLD-TDP, which is characterized by the presence of neuronal aggregates of TDP-43 protein.
V Van Deerlin and colleagues analyzed approximately 600 post-mortem cases of FTLD-TDP, with confirmed neuropathological evidence of TDP-43 aggregates. The scientists find that a common genetic variant at chromosome 7p21 is associated with increased risk of FTLD-TDP.
doi: 10.1038/ng.536
Research highlights
-
Nov 26
Evolution: Ancient bird sticks its big beak into the evolutionary recordNature
-
Nov 25
Zoology: Mineral armour discovered in insectsNature Communications
-
Nov 24
Neuroscience: Social isolation evokes craving responses in the human brainNature Neuroscience
-
Nov 20
Archaeology: Transition from tribal to feudal living in 14th century impacted local ecosystemsScientific Reports
-
Nov 18
Ecology: Migration associated with faster pace of lifeNature Communications
-
Nov 17
Gene therapy: Concerns for the long-term safety of AAV gene therapyNature Biotechnology
