CRLF2 defects in Down syndrome-associated leukemia
Nature Genetics
October 19, 2009
A chromosomal alteration that fuses the P2RY8 and CRLF2 genes is found in individuals with B-progenitor acute lymphoblastic leukemia (ALL) and ALL associated with Down syndrome (DS), according to a new study published online this week in Nature Genetics.
ALL is the most common childhood cancer, with a cure rate of 85% in children. Children with DS are approximately 10-20 times more likely to develop leukemia than non-DS children.
Charles Mullighan and colleagues report that a recurrent chromosomal deletion that leads to the P2RY8-CRLF2 fusion is found in 7% of individuals with B-progenitor ALL and 53% of individuals with Down syndrome-associated ALL. The fusion leads to elevated activity of the CRLF2 gene, which may contribute to the increased risk of ALL in children with DS.
doi: 10.1038/ng.469
Research highlights
-
Dec 4
Archaeology: Palaeolithic sea voyage to Japanese islands beyond the horizonScientific Reports
-
Dec 3
Ageing: Cellular rejuvenation restores vision in miceNature
-
Dec 1
Neurodegenerative disease: Two blood molecules may predict Alzheimer’s disease developmentNature Aging
-
Nov 27
Archaeology: Neanderthal thumbs better adapted to holding tools with handlesScientific Reports
-
Nov 26
Evolution: Ancient bird sticks its big beak into the evolutionary recordNature
-
Nov 26
Metabolism: Link between SARS-CoV-2 infection and cholesterol hints at COVID-19 treatment possibilitiesNature Metabolism
