Research highlight

Glioblastoma microvesicles typing in blood

Nature Medicine

November 12, 2012

A technology that can monitor gliobastoma response to therapy through the identification of tumor-released microvesicles in blood is reported in a paper published in Nature Medicine this week.

Ralph Weissleder and colleagues describe a sensitive technique that uses a microfluidic microchip for profiling proteins in microvesicles, which consist mostly of exosomes. The authors used both glioblastoma cell cultures and blood from patients with gioblastoma to show that the technique, which utilizes nanoparticles for labeling and a miniaturized nuclear magnetic resonance system for detection, can differentiate tumor-derived microvesicles from those derived from normal cells.

The technique could potentially be used to follow up treatment efficacy and to identify both primary tumor mutations and treatment-induced changes in cancer cells.

doi: 10.1038/nm.2994

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