Research highlight

Variants associated with prostate cancer

Nature Genetics

July 11, 2011

Genetic variants associated with prostate cancer are reported this week in Nature Genetics. These findings, together with previously reported susceptibility loci, may explain an up to 25% of the familial risk for prostate cancer.

Prostate cancer is the most common cancer diagnosed in men over 50 years of age in developed countries.

Rosalind Eeles and colleagues report a multi-stage genome-wide association study for prostate cancer in 4,574 cancer cases and 4,164 controls, with replication in an additional 51,311 individuals from 30 international studies. They identify seven genomic regions newly associated with prostate cancer susceptibility. This brings the number of identified prostate cancer susceptibility loci to over 40.

doi: 10.1038/ng.882

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