Research highlight

Variants associated with heart disease

Nature Genetics

March 7, 2011

Three independent studies in this week’s issue of Nature Genetics report genetic variants associated with increased risk of coronary artery disease (CAD).

Coronary artery disease is the leading cause of death worldwide, causing approximately 12% of all death. CAD is a condition caused by the narrowing of blood vessels that supply the heart with oxygenated blood.

Heribert Schunkert and colleagues performed an analysis of over 100,000 Europeans and identified 13 new genetic risk loci for CAD. In a second study, the Coronary Artery Disease Genetics Consortium report an analysis of 71,075 Europeans and South Asians and identified five loci newly associated with CAD. And finally, Qing K. Wang and colleagues analyzed 7,593 individuals of Han Chinese ancestry and identified one locus on chromosome 6q24.1 that was associated with CAD.Author contacts:Heribert Schunkert (Universitat zu Lubeck, Germany) Author paper [3]Tel: +49 451 500 2501; E-mail: heribert.schunkert@uk-sh.deHugh Watkins (University of Oxford, UK) Author paper [4]Tel: +44 1865 234657; E-mail: Kenneth Wang (Huazhong University of Science and Technology, Wuhan, China) Author paper [5]Tel: +86 2787794549; E-mail:

doi: 10.1038/ng.784

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