News
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Pioneering Alzheimer’s study in Colombia zeroes in on enigmatic protein p567
Researchers tracking a genetic mutation that causes an early-onset form of the disease hope to uncover new drug targets.
doi: 10.1038/d41586-018-03848-4
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Four-in-one 3D printer paves way for custom-made robots and phones p569
Experimental device is a route to printing smartphones and other electronics.
doi: 10.1038/d41586-018-03446-4
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Ocean scientists work to forecast huge plankton blooms in Arabian Sea p569
An operational forecast could help countries prepare for booms in these tiny marine creatures.
doi: 10.1038/d41586-018-03698-0
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Reduced-calorie diet shows signs of slowing ageing in people p570
Most comprehensive study yet demonstrates that cutting people’s energy intake turns down their metabolism.
doi: 10.1038/d41586-018-03431-x
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First space mission dedicated to exoplanet atmospheres gets green light p571
Scientists hope to learn what makes a ‘typical’ solar system from the European Space Agency’s €450-million probe.
doi: 10.1038/d41586-018-03445-5
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US science agencies set to win big in budget deal p572
Lawmakers are set to vote this week on legislation that includes significant funding increases for many science agencies.
doi: 10.1038/d41586-018-03700-9
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News & Views
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A trio of ion channels takes the heat p591
Of the various temperature-sensitive ion channels identified previously, three have now been found to act in concert to detect painful heat and initiate protective reflexes.
doi: 10.1038/d41586-018-02663-1
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Oceans on Mars formed early p592
The geometry of putative ancient shorelines on Mars suggests that these features were deformed by the growth of a massive volcanic region — a finding that has implications for the climate, geology and hydrology of early Mars.
doi: 10.1038/d41586-018-03415-x
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AI designs organic syntheses p592
Software that devises effective schemes for synthetic chemistry has depended on the input of rules from researchers. A system is now reported in which an artificial-intelligence program learns the rules for itself.
doi: 10.1038/d41586-018-03774-5
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Wing origami p594
Conventional origami-based techniques for structural design have a limited range of folding patterns. An approach inspired by the wings of earwigs produces structures that were not possible using previous methods.
doi: 10.1038/d41586-018-03775-4
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The healthy diabetic cavefish conundrum p595
Some Mexican cavefish have a mutation in an insulin receptor protein that affects blood-glucose regulation. The same mutation causes diabetes and health problems in humans, but the diabetic cavefish thrive.
doi: 10.1038/d41586-018-03242-0
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The tornadoes of sudden cardiac arrest p597
A clever combination of techniques has enabled, for the first time, simultaneous visualization of the 3D waves of electrical and mechanical activity that are responsible for many cases of sudden cardiac death.
doi: 10.1038/d41586-018-01950-1
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Article
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A coherent spin–photon interface in silicon p599
A single spin in silicon is strongly coupled to a microwave-frequency photon and coherent single-spin dynamics are observed using circuit quantum electrodynamics.
doi: 10.1038/nature25769
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Planning chemical syntheses with deep neural networks and symbolic AI p604
Deep neural networks and Monte Carlo tree search can plan chemical syntheses by training models on a huge database of published reactions; their predicted synthetic routes cannot be distinguished from those a human chemist would design.
doi: 10.1038/nature25978
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De novo mutations in regulatory elements in neurodevelopmental disorders p611
Analysis of rare de novo mutations in gene regulatory elements suggests that 1–3% of patients with neurodevelopmental disorders carry such mutations in elements that are active in the fetal brain.
doi: 10.1038/nature25983
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Encoding of danger by parabrachial CGRP neurons p617
Single-cell recordings show that CGRP-expressing neurons in the parabrachial nucleus in mice respond to both noxious stimuli and signals of feeding satiety.
doi: 10.1038/nature25511
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Extensive impact of non-antibiotic drugs on human gut bacteria p623
A screen of more than 1,000 drugs shows that about a quarter of the non-antibiotic drugs inhibit the growth of at least one commensal bacterial strain in vitro.
doi: 10.1038/nature25979
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Letter
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A galaxy lacking dark matter p629
Galaxies normally have far more dark matter than normal matter, but the dynamics of objects within the ultra-diffuse galaxy NGC1052–DF2 suggest that it has a very little dark matter component.
doi: 10.1038/nature25767
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A programmable two-qubit quantum processor in silicon p633
A two-qubit quantum processor in a silicon device is demonstrated, which can perform the Deutsch–Josza algorithm and the Grover search algorithm.
doi: 10.1038/nature25766
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Massive Dirac fermions in a ferromagnetic kagome metal p638
Fe
3Sn2 hosts massive Dirac fermions, owing to the underlying symmetry properties of the bilayer kagome lattice in the ferromagnetic state and the atomic spin–orbit coupling.
doi: 10.1038/nature25987
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Timing of oceans on Mars from shoreline deformation p643
Ancient shorelines on Mars must have formed before and during the emplacement of the Tharsis volcanic province, instead of afterwards as previously assumed, suggesting that oceans on Mars formed early.
doi: 10.1038/nature26144
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Insulin resistance in cavefish as an adaptation to a nutrient-limited environment p647
Cavefish populations of the Mexican tetra, Astyanax mexicanus, carry a mutation in the insulin receptor gene that renders them insulin- and starvation-resistant relative to surface populations of the same species.
doi: 10.1038/nature26136
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Reconstructing the genetic history of late Neanderthals p652
Genetic similarity among late Neanderthals is predicted well by their geographical location, and although some of these Neanderthals were contemporaneous with early modern humans, their genomes show no evidence of recent gene flow from modern humans.
doi: 10.1038/nature26151
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Moving magnetoencephalography towards real-world applications with a wearable system p657
A new magnetoencephalography system allows high-spatiotemporal-resolution imaging of human brain function in moving subjects.
doi: 10.1038/nature26147
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A TRP channel trio mediates acute noxious heat sensing p662
Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all three show severe deficits in heat sensing, whereas double-knockout mice do not.
doi: 10.1038/nature26137
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Electromechanical vortex filaments during cardiac fibrillation p667
Using optical mapping and 3D ultrasound, the dynamics and interactions between electrical and mechanical phase singularities were analysed by simultaneously measuring the membrane potential, intracellular calcium concentration and mechanical contractions of the heart during normal rhythm and fibrillation.
doi: 10.1038/nature26001
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Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance p673
Hepatocytes secrete DPP4, which promotes adipose tissue inflammation and insulin resistance in obese mice, suggesting a new specific target for treatment of metabolic disorders.
doi: 10.1038/nature26138
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The protein histidine phosphatase LHPP is a tumour suppressor p678
Decreased expression of histidine phosphatase LHPP, a novel tumour suppressor, results in increased global histidine phosphorylation and hepatocellular carcinoma.
doi: 10.1038/nature26140
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Optogenetic regulation of engineered cellular metabolism for microbial chemical production p683
Finely tuned optogenetic control of engineered Saccharomyces cerevisiae enhances the biosynthesis of valuable products such as isobutanol in laboratory-scale fermenters.
doi: 10.1038/nature26141
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