Molecular Cell Biology : Highlights
: Molecular Cell Biology Articles
Review: Heat shock factors: integrators of cell stress, development and lifespanHeat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress. They are best known as inducible transcriptional regulators of genes encoding molecular chaperones and other stress proteins. Four members of the HSF family are also important for normal development and Nature Reviews Molecular Cell Biology, vol. 11 #8, pp545-555 |
Review: Membrane budding and scission by the ESCRT machinery: it's all in the neckThe endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most unusual membrane remodelling events in cell biology. ESCRT-I and ESCRT-II direct membrane budding away from the cytosol by stabilizing bud necks without coating the buds and without being consumed in the buds. Nature Reviews Molecular Cell Biology, vol. 11 #8, pp556-566 |
Review: Progeria syndromes and ageing: what is the connection?One of the many debated topics in ageing research is whether progeroid syndromes are really accelerated forms of human ageing. The answer requires a better understanding of the normal ageing process and the molecular pathology underlying these rare diseases. Exciting recent findings regarding a severe Nature Reviews Molecular Cell Biology, vol. 11 #8, pp567-578 |
Review: The HSP70 chaperone machinery: J proteins as drivers of functional specificityHeat shock 70 kDa proteins (HSP70s) are ubiquitous molecular chaperones that function in a myriad of biological processes, modulating polypeptide folding, degradation and translocation across membranes, and protein?protein interactions. This multitude of roles is not easily reconciled with the universality of the activity of HSP70s Nature Reviews Molecular Cell Biology, vol. 11 #8, pp579-592 |
Perspectives: Lipidomics: coming to grips with lipid diversityAlthough lipids are biomolecules with seemingly simple chemical structures, the molecular composition of the cellular lipidome is complex and, currently, poorly understood. The exact mechanisms of how compositional complexity affects cell homeostasis and its regulation also remain unclear. This emerging field is developing sensitive mass Nature Reviews Molecular Cell Biology, vol. 11 #8, pp593-598 |
