Molecular Cell Biology Articles

Review: Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

The mitotic checkpoint is a major cell cycle control mechanism that guards against chromosome missegregation and the subsequent production of aneuploid daughter cells. Most cancer cells are aneuploid and frequently missegregate chromosomes during mitosis. Indeed, aneuploidy is a common characteristic of tumours, and, for over

Nature Reviews Molecular Cell Biology, vol. 10 #7, pp478-487

Review: Collective cell migration in morphogenesis, regeneration and cancer

The collective migration of cells as a cohesive group is a hallmark of the tissue remodelling events that underlie embryonic morphogenesis, wound repair and cancer invasion. In such migration, cells move as sheets, strands, clusters or ducts rather than individually, and use similar actin- and

Nature Reviews Molecular Cell Biology, vol. 10 #7, pp445-457

Perspectives: Bio-art: the ethics behind the aesthetics

Bio-art represents a crossover of art and the biological sciences, with living matter, such as genes, cells or animals, as its new media. Such manipulations of life require collaborations with scientists and considerable financial backing. Herein, I consider bio-art that goes 'under the skin' —

Nature Reviews Molecular Cell Biology, vol. 10 #7, pp496-500

Review: Dynamics and diversity in autophagy mechanisms: lessons from yeast

Autophagy is a fundamental function of eukaryotic cells and is well conserved from yeast to humans. The most remarkable feature of autophagy is the synthesis of double membrane-bound compartments that sequester materials to be degraded in lytic compartments, a process that seems to be mechanistically

Nature Reviews Molecular Cell Biology, vol. 10 #7, pp458-467

Perspectives: Clearing the way for mitosis: is cohesin a target?

In interphase, chromosomes are associated with proteins and RNAs that participate in many processes, such as DNA replication, transcription, recombination and repair of DNA damage. These components (for example, cohesin) might have to be removed during mitosis, as they might become obstacles that inhibit chromosome

Nature Reviews Molecular Cell Biology, vol. 10 #7, pp489-496

Review: Proximal events in Wnt signal transduction

The Wnt family of secreted ligands act through many receptors to stimulate distinct intracellular signalling pathways in embryonic development, in adults and in disease processes. Binding of Wnt to the Frizzled family of receptors and to low density lipoprotein receptor-related protein 5 (LRP5) or LRP6

Nature Reviews Molecular Cell Biology, vol. 10 #7, pp468-477



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