Molecular Cell Biology Articles

Review: Heat shock factors: integrators of cell stress, development and lifespan

Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress. They are best known as inducible transcriptional regulators of genes encoding molecular chaperones and other stress proteins. Four members of the HSF family are also important for normal development and

Nature Reviews Molecular Cell Biology, vol. 11 #8, pp545-555

Review: Membrane budding and scission by the ESCRT machinery: it's all in the neck

The endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most unusual membrane remodelling events in cell biology. ESCRT-I and ESCRT-II direct membrane budding away from the cytosol by stabilizing bud necks without coating the buds and without being consumed in the buds.

Nature Reviews Molecular Cell Biology, vol. 11 #8, pp556-566

Review: Progeria syndromes and ageing: what is the connection?

One of the many debated topics in ageing research is whether progeroid syndromes are really accelerated forms of human ageing. The answer requires a better understanding of the normal ageing process and the molecular pathology underlying these rare diseases. Exciting recent findings regarding a severe

Nature Reviews Molecular Cell Biology, vol. 11 #8, pp567-578

Review: The HSP70 chaperone machinery: J proteins as drivers of functional specificity

Heat shock 70 kDa proteins (HSP70s) are ubiquitous molecular chaperones that function in a myriad of biological processes, modulating polypeptide folding, degradation and translocation across membranes, and protein?protein interactions. This multitude of roles is not easily reconciled with the universality of the activity of HSP70s

Nature Reviews Molecular Cell Biology, vol. 11 #8, pp579-592

Perspectives: Lipidomics: coming to grips with lipid diversity

Although lipids are biomolecules with seemingly simple chemical structures, the molecular composition of the cellular lipidome is complex and, currently, poorly understood. The exact mechanisms of how compositional complexity affects cell homeostasis and its regulation also remain unclear. This emerging field is developing sensitive mass

Nature Reviews Molecular Cell Biology, vol. 11 #8, pp593-598



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