: Drug Discovery Articles
Review: Membrane transporters in drug developmentMembrane transporters can be major determinants of the pharmacokinetic, safety and efficacy profiles of drugs. This presents several key questions for drug development, including which transporters are clinically important in drug absorption and disposition, and which in vitro methods are suitable for studying drug Nature Reviews Drug Discovery, vol. 9 #3, pp215-236 |
Review: Protein aggregation diseases: pathogenicity and therapeutic perspectivesA growing number of diseases seem to be associated with inappropriate deposition of protein aggregates. Some of these diseases ? such as Alzheimer's disease and systemic amyloidoses ? have been recognized for a long time. However, it is now clear that ordered aggregation of pathogenic Nature Reviews Drug Discovery, vol. 9 #3, pp237-248 |
Perspectives: Challenges with advanced therapy medicinal products and how to meet themAdvanced therapy medicinal products (ATMPs), which include gene therapy medicinal products, somatic cell therapy medicinal products and tissue-engineered products, are at the cutting edge of innovation and offer a major hope for various diseases for which there are limited or no therapeutic options. They have Nature Reviews Drug Discovery, vol. 9 #3, pp195-201 |
