: Chemistry Articles
Editorial: Postgenomic chemical biologyChemical biology contributions will become increasingly important as we enter the second decade of the postgenomic era. Nature Chemical Biology, vol. 6 #9, pp631-631 |
News and Views: Post-translational modifications: A shift for the O-GlcNAc paradigmMany nuclear and cytoplasmic proteins are post-translationally modified by both O-GlcNAc and phosphate, but determining whether a single copy of a protein bears multiple modifications remains a challenge. A new analytic approach reveals a surprising correlation between phosphorylation and the O-GlcNAc modification. Nature Chemical Biology, vol. 6 #9, pp634-635 |
News and Views: Metalloenzymes: Natural product nitrosationMany natural products are decorated with oxygenated nitrogens, but enzymes capable of forming a stable nitroso species have been elusive. A new study reports the identification of a copper-containing C-nitrososynthase that tightly controls the oxidation state of an aromatic amine to yield the natural product 4-hydroxy-3-nitrosobenzamide. Nature Chemical Biology, vol. 6 #9, pp636-637 |
News and Views: Chemical ecology: Reprogramming a termite monarchySubterranean termite colonies are founded by a single king and queen. However, the king generally outlives the queen, and an optimal number of secondary termite queens must be produced to meet the reproductive needs of the colony. A recent study explains the chemical basis of this biological process. Nature Chemical Biology, vol. 6 #9, pp637-638 |
News and Views: Screening: Your brain on drugsManipulation of stem cells is an important therapeutic goal that has proven difficult to achieve. A recent report describes a novel in vivo small-molecule screen and identifies a modulator of mammalian neurogenesis that partially reverses age-related declines in cognition. Nature Chemical Biology, vol. 6 #9, pp639-640 |
