: Cancer Articles
Review: Targeting the dynamic HSP90 complex in cancerThe molecular chaperone heat shock protein 90 (HSP90) has been used by cancer cells to facilitate the function of numerous oncoproteins, and it can be argued that cancer cells are 'addicted' to HSP90. However, although recent reports of the early clinical efficacy of HSP90 inhibitors Nature Reviews Cancer, vol. 10 #8, pp537-549 |
Review: Human papillomavirus oncoproteins: pathways to transformationAn association between human papillomavirus (HPV) infection and the development of cervical cancer was initially reported over 30 years ago, and today there is overwhelming evidence that certain subtypes of HPV are the causative agents of these malignancies. The p53 and retinoblastoma proteins are well-characterized Nature Reviews Cancer, vol. 10 #8, pp550-560 |
Review: IAPs: from caspase inhibitors to modulators of NF-?B, inflammation and cancerThe realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many types of human cancer and are associated with chemoresistance, disease progression and poor prognosis, has sparked a worldwide frenzy in the development of small pharmacological inhibitors of IAPs. The development of Nature Reviews Cancer, vol. 10 #8, pp561-574 |
Review: Targeting the ANGPT?TIE2 pathway in malignancyAngiopoietins (ANGPTs) are ligands of the endothelial cell receptor TIE2 and have crucial roles in the tumour angiogenic switch. Increased expression of ANGPT2 relative to ANGPT1 in tumours correlates with poor prognosis. The biological effects of the ANGPT?TIE system are context dependent, which brings into Nature Reviews Cancer, vol. 10 #8, pp575-585 |
Perspectives: The shunt problem: control of functional shunting in normal and tumour vasculatureNetworks of blood vessels in normal and tumour tissues have heterogeneous structures, with widely varying blood flow pathway lengths. To achieve efficient blood flow distribution, mechanisms for the structural adaptation of vessel diameters must be able to inhibit the formation of functional shunts (whereby short Nature Reviews Cancer, vol. 10 #8, pp587-593 |
