: Cancer Articles
Review: Eph receptors and ephrins in cancer: bidirectional signalling and beyondThe Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression patterns in cancer cells and tumour blood vessels, which suggest important roles for their bidirectional signals in many aspects of cancer development and progression. Eph gene mutations probably also contribute to cancer pathogenesis. Nature Reviews Cancer, vol. 10 #3, pp165-180 |
Review: Eicosanoids and cancerEicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that have been implicated in various pathological processes, such as inflammation and cancer. This Review highlights our understanding of the intricate roles of eicosanoids in epithelial-derived tumours and their microenvironment. The knowledge of how these lipids Nature Reviews Cancer, vol. 10 #3, pp181-193 |
Review: Microtubules and resistance to tubulin-binding agentsMicrotubules are dynamic structures composed of ???-tubulin heterodimers that are essential in cell division and are important targets for cancer drugs. Mutations in ?-tubulin that affect microtubule polymer mass and/or drug binding are associated with resistance to tubulin-binding agents such as paclitaxel. The aberrant expression Nature Reviews Cancer, vol. 10 #3, pp194-204 |
Perspectives: Breast and prostate cancer: more similar than differentBreast cancer and prostate cancer are the two most common invasive cancers in women and men, respectively. Although these cancers arise in organs that are different in terms of anatomy and physiological function both organs require gonadal steroids for their development, and tumours that arise Nature Reviews Cancer, vol. 10 #3, pp205-212 |
Perspectives: Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancerThe year 2009 marked the fiftieth anniversary of the first successful allogeneic haematopoietic stem cell transplant (HSCT). The field of HSCT has pioneered some of the most exciting areas of research today. HSCT was the original stem cell therapy, the first cancer immune therapy and Nature Reviews Cancer, vol. 10 #3, pp213-221 |
Perspectives: Dissecting cancer through mathematics: from the cell to the animal modelThis Timeline article charts progress in mathematical modelling of cancer over the past 50 years, highlighting the different theoretical approaches that have been used to dissect the disease and the insights that have arisen. Although most of this research was conducted with little involvement from Nature Reviews Cancer, vol. 10 #3, pp221-230 |
