last updated April 2013
Divining the path to effective intervention
A new study design is set to determine the best approaches to prevent bone and mineral disorders in patients with chronic kidney disease
The factors that contribute to better survival of patients undergoing dialysis treatment for chronic kidney disease will be identified in an observational study designed by a research team from several research institutes in Japan1. The results will guide the assessment of specific interventions to prevent complications in these patients.
An elevated level of the parathyroid hormone is a secondary consequence of chronic kidney disease that can cause bone and mineral disorders and eventually affect survival. In 2006, Japan issued guidelines to better treat this condition and improve survival; however, exactly which approaches should be implemented remain unclear owing to a lack of data linking patient profiles and their clinical management with survival.
Led by Shunichi Fukuhara of Kyoto University and iHope International, Kyoto, the research team has proposed a three-year observational study of dialysis patients with elevated parathyroid levels at several large dialysis centers in Japan. The team plans to collect data on the patients’ medical history, their treatment history over the study period, periodical results of their blood chemistries during the study, and incidence of mortality and other patient-level outcomes.
The team anticipates that analyzing those data together will allow them to draw conclusions regarding the benefit of specific interventions, which can be tested more directly in future studies.